Arrhythmogenic ventricular cardiomyopathy (AVC) is generally referred to as
arrhythmogenic right ventricular (RV) cardiomyopathy/dysplasia and constitutes an inherited …

Desmosomes have long been appreciated as intercellular junctions that are vital for
maintaining the structural integrity of stratified epithelia. More recent clinical investigations of …

Arrhythmogenic cardiomyopathy (ACM) is an inherited disorder characterized by structural
and electrical cardiac abnormalities, including myocardial fibro-fatty replacement. Its …

Heart failure (HF) is a complex pathophysiological syndrome that arises from a primary
defect in the ability of the heart to take in and/or eject sufficient blood. Genetic mutations …

Inherited arrhythmias, such as cardiomyopathies and cardiac ion channelopathies, along
with coronary heart disease (CHD) are three most common disorders that predispose adults …

Hereditary cardiomyopathies (CMPs), including arrhythmogenic cardiomyopathy (ACM),
dilated cardiomyopathy (DCM), and hypertrophic cardiomyopathy (HCM), represent a group …

Plakin proteins form critical connections between cell junctions and the cytoskeleton; their
disruption within epithelial and cardiac muscle cells cause skin-blistering diseases and …

Genetic variation modulates gene expression transcriptionally or post-transcriptionally, and
can profoundly alter an individual's phenotype. Measuring allelic differential expression at …

Aims To examine the relevance and cause of reduced plakoglobin IF in intercalated discs for
arrhythmogenic right ventricular cardiomyopathy (ARVC) and ARVC-like disease in mouse …

Sudden cardiac death (SCD) is responsible for a large proportion of non-traumatic, sudden
and unexpected deaths in young individuals. Sudden cardiac death is a known …