Nearly half of all adults with type 2 diabetes mellitus (T2DM) live in India and China. These
populations have an underlying predisposition to deficient insulin secretion, which has a key …

Diabetes, a complex multisystem metabolic disorder characterized by hyperglycemia, leads
to complications that reduce quality of life and increase mortality. Diabetes pathophysiology …

Abstract Type 2 diabetes (T2D) is a complex chronic disease characterized by considerable
phenotypic heterogeneity. In this study, we applied a reverse graph embedding method to …

Background Cluster algorithms are gaining in popularity in biomedical research due to their
compelling ability to identify discrete subgroups in data, and their increasing accessibility in …

The current classification of diabetes, based on hyperglycaemia, islet-directed antibodies
and some insufficiently defined clinical features, does not reflect differences in aetiological …

Background Heterogeneity in type 2 diabetes presentation and progression suggests that
precision medicine interventions could improve clinical outcomes. We undertook a …

The Precision Medicine in Diabetes Initiative (PMDI) was launched in 2018 by the American
Diabetes Association (ADA) in collaboration with the European Association for the Study of …

The historical subclassification of diabetes into predominantly types 1 and 2 is well
appreciated to inadequately capture the heterogeneity seen in patient presentations …

Artificial intelligence (AI) use in diabetes care is increasingly being explored to personalise
care for people with diabetes and adapt treatments for complex presentations. However, the …

Diabetes is a highly heterogeneous condition; yet, it is diagnosed by measuring a single
blood-borne metabolite, glucose, irrespective of aetiology. Although pragmatically helpful …