The emergence of the replication of RNA oligonucleotides was a critical step in the origin of
life. An important model for the study of nonenzymatic template copying, which would be a …

The traditional route to investigating biology by perturbing living systems or by individually
purifying and characterizing component parts is giving way to more complex endeavors …

The emergence of primordial RNA-based life would have required the abiotic synthesis of
nucleotides, and their participation in nonenzymatic RNA replication. Although considerable …

Hybridization of short nucleic acid segments (< 4 nt) to single-strand templates occurs as a
critical intermediate in processes such as nonenzymatic nucleic acid replication and toehold …

The nonenzymatic polymerization of RNA may have enabled copying of functional
sequences during the origin of life. Recent progress utilizing 5′-phosphoro-2 …

The copying of short DNA or RNA sequences in the absence of enzymes is a fascinating
reaction that has been studied in the context of prebiotic chemistry. It involves the …

The RNA World hypothesis posits that RNA was the molecule of both heredity and function
during the emergence of life. This hypothesis implies that RNA templates can be copied, and …

The nonenzymatic copying of RNA templates with imidazole-activated nucleotides is a well-
studied model for the emergence of RNA self-replication during the origin of life. We have …

The spontaneous emergence of long RNA molecules on the early Earth, a phenomenon
central to the RNA World hypothesis, continues to remain an enigma in the field of origins of …

Nonenzymatic RNA primer extension by activated mononucleotides has long served as a
model for the study of prebiotic RNA copying. We have recently shown that the rate of primer …