Zoonotic and related infections pose an enormous health threat to the world's second-most
populous continent. Despite the challenges faced by drug discovery scientists in Africa …

New antibiotics with either a novel mode of action or novel mode of inhibition are urgently
needed to overcome the threat of drug-resistant tuberculosis (TB). The present study profiles …

Introduction Despite substantial progress in the field, malaria remains a global health issue
and currently available control strategies are not sufficient to achieve eradication. Agents …

Fostering drug discovery and development in Africa | Nature Medicine Skip to main content Thank
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Amodiaquine (AQ) is a potent antimalarial drug used in combination with artesunate as part
of artemisinin-based combination therapies (ACTs) for malarial treatment. Due to the rising …

Malaria is a prevalent vector‐borne infectious disease in tropical regions, particularly in the
absence of effective vaccines and because of the emergence resistance of Plasmodium to …

Hydroxyethylamine (HEA)-based novel compounds were synthesized and their activity
against Plasmodium falciparum 3D7 was assessed, identifying a few hits without any …

Malaria remains a public health problem and a leading cause of death worldwide.
Consequently, the discovery of novel agents, including substances from medicinal plants, is …

Current malaria treatments are threatened by drug resistance, and new drugs are urgently
needed. In a phenotypic screen for new antimalarials, we identified (S)-SW228703 ((S) …

2, 6-Diazaspiro [3.4] octane-1, 3-dione, integrating β-lactam and γ-lactam into one structure,
is an important skeleton found in many bioactive molecules. This article describes a simple …