The excitability of spinal motoneurons is both fundamental for motor behavior and essential
in diagnosis of neural disorders. There are two mechanisms for altering this excitability. The …

There are now a reasonable number of invertebrate central pattern generator (CPG) circuits
described in sufficient detail that a mechanistic explanation of how they work is possible …

Ion channel mutations are an important cause of rare Mendelian disorders affecting brain,
heart, and other tissues. We performed parallel exome sequencing of 237 channel genes in …

Altered neuronal excitability is emerging as an important feature in Alzheimer's disease
(AD). Kv2. 1 potassium channels are important modulators of neuronal excitability and …

Brain-derived neurotrophic factor (BDNF) has been reported to play a critical role in
modulating plasticity in developing sensory cortices. In the visual cortex, maturation of …

Neuronal spike encoding and synaptic transmission in the brain need be precise and
reliable for well-organized behavior and cognition. Little is known about how a unitary …

This article extends previous work on evolving learning without synaptic plasticity from
discrete tasks to continuous tasks. Continuous-time recurrent neural networks without …

In neurons, spike timing is determined by integration of synaptic potentials in delicate
concert with intrinsic properties. Although the integration time is functionally crucial, it …

Background The neurons and synapses work coordinately to program the brain codes of
controlling cognition and behaviors. Spike patterns at the presynaptic neurons regulate …

In this article, we evolve and analyze continuous-time recurrent neural networks capable of
associating the smells of different foods with edibility or inedibility in different environments …