Stem cell-derived CAR T cells show greater persistence, trafficking, and viral control compared to ex vivo transduced CAR T cells
Adoptive cell therapy (ACT) using T cells expressing chimeric antigen receptors (CARs) is
an area of intense investigation in the treatment of malignancies and chronic viral infections …
an area of intense investigation in the treatment of malignancies and chronic viral infections …
Efficient manufacturing and engraftment of CCR5 gene-edited HSPCs following busulfan conditioning in nonhuman primates
J Murray, T Einhaus, R Venkataraman, S Radtke… - … Therapy-Methods & …, 2023 - cell.com
Hematopoietic stem cell gene therapy has been successfully used for a number of genetic
diseases and is also being explored for HIV. However, toxicity of the conditioning regimens …
diseases and is also being explored for HIV. However, toxicity of the conditioning regimens …
CD20 CAR T cells safely and reversibly ablate B cell follicles in a non-human primate model of HIV persistence
Chimeric antigen receptor (CAR) T cell therapies have demonstrated immense clinical
success for B cell and plasma cell malignancies. We tested their impact on the viral reservoir …
success for B cell and plasma cell malignancies. We tested their impact on the viral reservoir …
Intracellular RNase activity dampens zinc finger nuclease-mediated gene editing in hematopoietic stem and progenitor cells
CW Peterson, R Venkataraman, SS Reddy… - … Therapy-Methods & …, 2022 - cell.com
Over the past decade, numerous gene-editing platforms which alter host DNA in a highly
specific and targeted fashion have been described. Two notable examples are zinc finger …
specific and targeted fashion have been described. Two notable examples are zinc finger …
[HTML][HTML] AMD3100 redosing fails to repeatedly mobilize hematopoietic stem cells in the nonhuman primate and humanized mouse
Highlights•Hematopoietic stem cell mobilization is necessary for gene therapy and
transplants.•AMD3100 (Plerixafor) is the only mobilization agent safe in sickle cell …
transplants.•AMD3100 (Plerixafor) is the only mobilization agent safe in sickle cell …
Identification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells
The preclinical development of hematopoietic stem cell (HSC) gene therapy/editing and
transplantation protocols is frequently performed in large animal models such as nonhuman …
transplantation protocols is frequently performed in large animal models such as nonhuman …
[HTML][HTML] The Pigtail Macaque (Macaca nemestrina) in Biomedical Research
CE Hotchkiss - nprcresearch.org
The Macaca nemestrina (pigtail macaques) is an invaluable non-human primate model that
has been utilized to support research in the areas of reproduction and development …
has been utilized to support research in the areas of reproduction and development …