Large-scale plasma proteomics comparisons through genetics and disease associations
High-throughput proteomics platforms measuring thousands of proteins in plasma combined
with genomic and phenotypic information have the power to bridge the gap between the …
with genomic and phenotypic information have the power to bridge the gap between the …
The physiological and pathological role of acyl-coA oxidation
S Szrok-Jurga, A Czumaj, J Turyn… - International Journal of …, 2023 - mdpi.com
Fatty acid metabolism, including β-oxidation (βOX), plays an important role in human
physiology and pathology. βOX is an essential process in the energy metabolism of most …
physiology and pathology. βOX is an essential process in the energy metabolism of most …
Microvascular and macrovascular complications of type 2 diabetes mellitus: Exome wide association analyses
Background Type 2 diabetes mellitus (T2DM) is a chronic, metabolic disorder in which
concomitant insulin resistance and β-cell impairment lead to hyperglycemia, influenced by …
concomitant insulin resistance and β-cell impairment lead to hyperglycemia, influenced by …
Genome-wide association studies of thyroid-related hormones, dysfunction, and autoimmunity among 85,421 Chinese pregnancies
Maintaining normal thyroid function is crucial in pregnancy, yet thyroid dysfunction and the
presence of thyroid peroxidase antibodies (TPOAb) affect 0.5% to 18% of pregnant women …
presence of thyroid peroxidase antibodies (TPOAb) affect 0.5% to 18% of pregnant women …
Proteogenomic analysis integrated with electronic health records data reveals disease-associated variants in Black Americans
UA Tahir, JL Barber, DE Cruz, ME Kars, S Deng… - The Journal of Clinical …, 2024 - jci.org
BACKGROUND Most GWAS of plasma proteomics have focused on White individuals of
European ancestry, limiting biological insight from other ancestry-enriched protein …
European ancestry, limiting biological insight from other ancestry-enriched protein …
Common risk alleles for schizophrenia within the major histocompatibility complex predict white matter microstructure
Recent research has highlighted the role of complement genes in shaping the
microstructure of the brain during early development, and in contributing to common allele …
microstructure of the brain during early development, and in contributing to common allele …
Nanoparticle enrichment mass-spectrometry proteomics identifies protein-altering variants for precise pQTL mapping
Proteogenomics studies generate hypotheses on protein function and provide genetic
evidence for drug target prioritization. Most previous work has been conducted using affinity …
evidence for drug target prioritization. Most previous work has been conducted using affinity …
Vitamin D status affects proteomic profile of HDL-associated proteins and inflammatory mediators in dyslipidemia
Vitamin D deficiency and dyslipidemia have substantial implications for human health
globally. Vitamin D is essential for bone metabolism and immune modulation, and its …
globally. Vitamin D is essential for bone metabolism and immune modulation, and its …
Proteomic Analysis of Prehypertensive and Hypertensive Patients: Exploring the Role of the Actin Cytoskeleton
S Al Ashmar, GG Anlar, H Krzyslak, L Djouhri… - International Journal of …, 2024 - mdpi.com
Hypertension is a pervasive and widespread health condition that poses a significant risk
factor for cardiovascular disease, which includes conditions such as heart attack, stroke, and …
factor for cardiovascular disease, which includes conditions such as heart attack, stroke, and …
Multi-population GWAS detects robust marker associations in a newly established six-rowed winter barley breeding program
CK Skovbjerg, P Sarup, E Wahlström, JD Jensen… - Heredity, 2024 - nature.com
Genome-wide association study (GWAS) is a powerful tool for identifying marker-trait
associations that can accelerate breeding progress. Yet, its power is typically constrained in …
associations that can accelerate breeding progress. Yet, its power is typically constrained in …