What changes in brain function cause the debilitating symptoms of depression? Can we use
the answers to this question to invent more effective, faster acting antidepressant drug …

Matrix metalloproteinases (MMPs) are physiologically expressed in the central nervous
system in neurons, astrocytes and microglia, and their aberrant elevation contributes to a …

Sepsis-associated encephalopathy (SAE) is commonly defined as diffuse brain dysfunction
and can manifest as delirium to coma. Accumulating evidence has suggested that …

Major depressive disorder is a complex disease resulting from aberrant synaptic plasticity
that may be caused by abnormal serotonergic signaling. Using a combination of behavioral …

Perineuronal nets (PNNs) are specialized structures of the extracellular matrix that surround
the soma and proximal dendrites of certain neurons in the central nervous system …

Major depressive disorder (MDD) is widely accepted as having a heterogenous
pathophysiology involving a complex mixture of systemic and CNS processes. A …

Major depression (MD) is one of the most common psychiatric disorders worldwide.
Currently, the first-line treatment for MD targets the serotonin system but these drugs, notably …

Perineuronal nets (PNNs) are condensed extracellular matrix (ECM) structures found
throughout the central nervous system that regulate plasticity. They consist of a …

Mood disorders are associated with hypothalamic-pituitary-adrenal axis overactivity
resulting from a decreased inhibitory feedback exerted by the hippocampus on this brain …

RNA N6-methyladenosine (m6A) modification represents another layer of gene regulation.
Fat mass and obesity-related protein (FTO) is the main N6-methyladenosine demethylase …