Environmental enrichment (EE) has been widely used as a means to enhance brain
plasticity mechanisms (eg, increased dendritic branching, synaptogenesis, etc.) and improve …

Stroke is among the most common causes of adult disability worldwide, and its disease
burden is shifting towards that of a long-term condition. Therefore, the development of …

Maintenance of cerebral blood vessel integrity and regulation of cerebral blood flow ensure
proper brain function. The adult human brain represents only a small portion of the body …

Although poststroke aerobic exercise (AE) increases markers of neuroplasticity and protects
perilesional tissue, the degree to which it enhances complex motor or cognitive outcomes is …

Aging, a complex process associated with various structural, functional and metabolic
changes in the brain, is an important risk factor for neurodegenerative diseases and stroke …

Background and Purpose: There is a need to translate promising basic research about
environmental enrichment to clinical stroke settings. The aim of this study was to assess the …

Background: There is increasing evidence that angiogenesis, through new blood vessel
formation, results in improved collateral circulation and may impact the long-term recovery of …

Objective To evaluate whether cognitive and motor therapy (CMT) is more effective than no
therapy, motor therapy, or cognitive therapy on motor and/or cognitive outcomes after stroke …

Brief bouts of sublethal ischemia have been shown to protect exposed tissue (ischemic
conditioning) and tissues at remote sites (remote ischemic conditioning) against subsequent …

Injury to the central nervous system (CNS) can leave patients with devastating neurological
deficits that may permanently impair independence and diminish quality of life. Recent …