Centella asiatica: phytochemistry and mechanisms of neuroprotection and cognitive enhancement

NE Gray, A Alcazar Magana, P Lak, KM Wright… - Phytochemistry …, 2018 - Springer
This review describes in detail the phytochemistry and neurological effects of the medicinal
herb Centella asiatica (L.) Urban. C. asiatica is a small perennial plant that grows in moist …

Flavonoids as a natural enhancer of neuroplasticity—An overview of the mechanism of neurorestorative action

N Cichon, J Saluk-Bijak, L Gorniak, L Przyslo, M Bijak - Antioxidants, 2020 - mdpi.com
Neuroplasticity is a complex physiological process occurring in the brain for its entire life.
However, it is of particular importance in the case of central nervous system (CNS) …

[HTML][HTML] Recent updates in neuroprotective and neuroregenerative potential of Centella asiatica

Y Lokanathan, N Omar, NNA Puzi, A Saim… - The Malaysian journal …, 2016 - ncbi.nlm.nih.gov
Centella asiatica, locally well known in Malaysia as pegaga, is a traditional herb that has
been used widely in Ayurvedic medicine, traditional Chinese medicine, and in the traditional …

Pathogenesis of Huntington's disease: an emphasis on molecular pathways and prevention by natural remedies

Z Irfan, S Khanam, V Karmakar, SM Firdous… - Brain Sciences, 2022 - mdpi.com
Background: Huntington's disease is an inherited autosomal dominant trait neuro-
degenerative disorder caused by changes (mutations) of a gene called huntingtin (htt) that is …

Rutin protects against neuronal damage in vitro and ameliorates doxorubicin-induced memory deficits in vivo in Wistar rats

GV Ramalingayya, SP Cheruku, PG Nayak… - Drug design …, 2017 - Taylor & Francis
Doxorubicin (DOX) is the most widely used broad-spectrum anticancer agent, either alone or
in combination, for most cancers including breast cancer. Long-term use of …

Caffeoylquinic acids in Centella asiatica protect against amyloid-β toxicity

NE Gray, J Morré, J Kelley, CS Maier… - Journal of …, 2014 - content.iospress.com
The accumulation of amyloid-ß (Aß) is a hallmark of Alzheimer's disease and is known to
result in neurotoxicity both in vivo and in vitro. We previously demonstrated that treatment …

Pharmacokinetics of a standardized extract of Centella asiatica ECa 233 in rats

T Anukunwithaya, MH Tantisira, B Tantisira… - Planta …, 2017 - thieme-connect.com
ECa 233, a standardized extract of Centella asiatica, has been found to exhibit various
positive neurological effects and to have a good safety profile. The present study aimed to …

Neuroprotective effect of a standardized extract of Centella asiatica ECa233 in rotenone-induced parkinsonism rats

N Teerapattarakan, H Benya-Aphikul, R Tansawat… - Phytomedicine, 2018 - Elsevier
Background Mitochondrial dysfunction and reactive oxygen species (ROS) generation
cause dopaminergic neurodegeneration in Parkinson's disease. The neuroprotective …

Centella asiatica attenuates Aβ-induced neurodegenerative spine loss and dendritic simplification

NE Gray, JA Zweig, C Murchison, M Caruso… - Neuroscience …, 2017 - Elsevier
The medicinal plant Centella asiatica has long been used to improve memory and cognitive
function. We have previously shown that a water extract from the plant (CAW) is …

Induction of keratinocyte migration by ECa 233 is mediated through FAK/Akt, ERK, and p38 MAPK signaling

S Singkhorn, MH Tantisira, S Tanasawet… - Phytotherapy …, 2018 - Wiley Online Library
Centella asiatica is widely considered the most important medicinal plant for treating and
relieving skin diseases. Recently developed standardized extract of Centella asiatica ECa …