Targeting apoptosis and autophagy following spinal cord injury: Therapeutic approaches to polyphenols and candidate phytochemicals

F Abbaszadeh, S Fakhri, H Khan - Pharmacological Research, 2020 - Elsevier
Spinal cord injury (SCI) is a neurological disorder associated with the loss of sensory and
motor function. Understanding the precise dysregulated signaling pathways, especially …

Parthanatos in the pathogenesis of nervous system diseases

X Wang, P Ge - Neuroscience, 2020 - Elsevier
Parthanatos is a modality of regulated cell death initiated by poly (ADP-ribose) polymerase 1
(PARP-1) hyperactivation and characterized by apoptosis inducing factor (AIF)-dependent …

Antioxidant, anti-inflammatory and neuroprotective actions of resveratrol after experimental nervous system insults. Special focus on the molecular mechanisms …

CA Miguel, MV Noya-Riobó, GL Mazzone… - Neurochemistry …, 2021 - Elsevier
After different types of acute central nervous system insults, including stroke, subarachnoid
haemorrhage and traumatic brain and spinal cord injuries, secondary damage plays a …

Grape (Vitis vinifera L.) phytochemicals and their biochemical protective mechanisms against leading pathologies

U Majeed, A Shafi, H Majeed, K Akram, X Liu, J Ye… - Food Chemistry, 2023 - Elsevier
The intake of herbal dietary constituents, mostly fruits and vegetables, have been
considered well-known to prevent pathologies (degenerative diseases). Consumer …

[HTML][HTML] Different ways to die: cell death pathways and their association with spinal cord injury

L Guha, N Singh, H Kumar - Neurospine, 2023 - ncbi.nlm.nih.gov
Cell death is a systematic/nonsystematic process of cessation of normal morphology and
functional properties of the cell to replace and recycle old cells with new also promoting …

Activity-dependent plasticity and spinal cord stimulation for motor recovery following spinal cord injury

S Samejima, R Henderson, J Pradarelli… - Experimental …, 2022 - Elsevier
Spinal cord injuries lead to permanent physical impairment despite most often being
anatomically incomplete disruptions of the spinal cord. Remaining connections between the …

Exosome-mediated repair of spinal cord injury: a promising therapeutic strategy

T Yu, LL Yang, Y Zhou, MF Wu, JH Jiao - Stem Cell Research & Therapy, 2024 - Springer
Spinal cord injury (SCI) is a catastrophic injury to the central nervous system (CNS) that can
lead to sensory and motor dysfunction, which seriously affects patients' quality of life and …

Mechanism of neuroprotection against experimental spinal cord injury by riluzole or methylprednisolone

C Sámano, A Nistri - Neurochemical research, 2019 - Springer
Any spinal cord injury carries the potential for persistent disability affecting motor, sensory
and autonomic functions. To prevent this outcome, it is highly desirable to block a chain of …

Evaluating accessibility of intravenously administered nanoparticles at the lesion site in rat and pig contusion models of spinal cord injury

Y Gao, S Vijayaraghavalu, M Stees, BK Kwon… - Journal of Controlled …, 2019 - Elsevier
In spinal cord injury (SCI), timely therapeutic intervention is critical to inhibit the post-injury
rapidly progressing degeneration of spinal cord. Towards that objective, we determined the …

Neuroprotective gap-junction-mediated bystander transformations in the adult zebrafish spinal cord after injury

A Pedroni, YWE Dai, L Lafouasse, W Chang… - Nature …, 2024 - nature.com
The adult zebrafish spinal cord displays an impressive innate ability to regenerate after
traumatic insults, yet the underlying adaptive cellular mechanisms remain elusive. Here, we …