Role of PI3K-AKT-mTOR pathway as a pro-survival signaling and resistance-mediating mechanism to therapy of prostate cancer

T Pungsrinont, J Kallenbach, A Baniahmad - International journal of …, 2021 - mdpi.com
Androgen deprivation therapy (ADT) and androgen receptor (AR)-targeted therapy are the
gold standard options for treating prostate cancer (PCa). These are initially effective, as …

The WNT/β‐catenin dependent transcription: A tissue‐specific business

S Söderholm, C Cantù - WIREs Mechanisms of Disease, 2021 - Wiley Online Library
Abstract β‐catenin‐mediated Wnt signaling is an ancient cell‐communication pathway in
which β‐catenin drives the expression of certain genes as a consequence of the trigger …

Genetic aberrations of DNA repair pathways in prostate cancer: translation to the clinic

A Ghose, M Moschetta, G Pappas-Gogos… - International Journal of …, 2021 - mdpi.com
Prostate cancer (PC) is the second most common cancer in men worldwide. Due to the large-
scale sequencing efforts, there is currently a better understanding of the genomic landscape …

Androgen receptor-dependent mechanisms mediating drug resistance in prostate cancer

M Ehsani, FO David, A Baniahmad - Cancers, 2021 - mdpi.com
Simple Summary Prostate cancer can develop under hormone treatment and chemotherapy
from a castration-sensitive towards a castration-resistant into a drug resistant-tumor. The …

Distinct mechanisms mediating therapy-induced cellular senescence in prostate cancer

J Kallenbach, G Atri Roozbahani, M Heidari Horestani… - Cell & Bioscience, 2022 - Springer
Abstract Background Prostate cancer (PCa) is an age-related malignancy in men with a high
incidence rate. PCa treatments face many obstacles due to cancer cell resistance and many …

Natural products for the management of castration-resistant prostate cancer: Special focus on nanoparticles based studies

RK Singla, CS Sai, H Chopra, S Behzad… - Frontiers in cell and …, 2021 - frontiersin.org
Prostate cancer is the most common type of cancer among men and the second most
frequent cause of cancer-related mortality around the world. The progression of advanced …

Androgen receptor activation induces senescence in thyroid cancer cells

A Gupta, M Carnazza, M Jones, Z Darzynkiewicz… - Cancers, 2023 - mdpi.com
Simple Summary Thyroid cancer is the most common endocrine malignancy and occurs
three times more frequently in women than in men. Further, androgen receptor expression is …

Cellular senescence: ageing and androgenetic alopecia

YDMWYHFL LingnaChen, X Xiong - Dermatology, 2023 - karger.com
Androgenetic alopecia (AGA) is the most common type of hair loss and features progressive
miniaturization of hair follicles. Generally, the occurrence of AGA has long been thought to …

Combined anti-cancer effects of platycodin D and sorafenib on androgen-independent and PTEN-deficient prostate cancer

Z Lu, W Song, Y Zhang, C Wu, M Zhu, H Wang… - Frontiers in …, 2021 - frontiersin.org
Castration-resistant (androgen-independent) and PTEN-deficient prostate cancer is a
challenge in clinical practice. Sorafenib has been recommended for the treatment of this …

Identification of metabolism-associated prostate cancer subtypes and construction of a prognostic risk model

Y Zhang, R Zhang, F Liang, L Zhang, X Liang - Frontiers in Oncology, 2020 - frontiersin.org
Background Despite being the second most common tumor in men worldwide, the tumor
metabolism-associated mechanisms of prostate cancer (PCa) remain unclear. Herein, this …