Childhood obesity is an alarming public health problem. The pediatric obesity rate has
quadrupled in the past 30 years, and currently nearly 20% of United States children and 9 …

Childhood obesity and its associated comorbidities are highly prevalent diseases that may
add to any other possible health problem commonly affecting the pediatric age …

Implant surgery is a lengthy dental procedure, and sedation is often used to reduce
discomfort. The effectiveness of sedation has traditionally been evaluated in terms of patient …

OBJECTIVE Characterize levetiracetam pharmacokinetics (PK) in children with obesity to
inform dosing. METHODS Children 2 to< 21 years old receiving standard of care oral …

The incidence of paediatric obesity continues to rise worldwide and contributes to a range of
diseases including cardiovascular disease. Obesity in children has been shown to impact …

Midazolam is an established probe drug to assess cytochrome P450 3A activity
(phenotyping). Microdosed midazolam is increasingly used for this purpose; a buccal …

Drug administration is crucial to achieve effective therapeutic drug outcomes. In medical
emergencies, it is particularly convenient to use drugs that could be administered as an …

La vía de administración de un fármaco constituye un punto clave para que este alcance su
diana terapéutica y pueda ejercer el efecto terapéutico deseado. En urgencias y …

Objective Methadone is used to prevent opioid iatrogenic withdrawal syndrome (IWS) in
children, but the optimal dose and overlap time with an opioid infusion have not been …

Background The sedative effect of intraoperative sedation in elderly surgery exerts critical
influence on the prognosis. Comparison on the safety and efficacy between …