Chemokines and cytokines are critical for initiating and coordinating the organized and
sequential recruitment and activation of cells into Mycobacterium tuberculosis-infected …

Tuberculosis is a major cause of death around the world, with most of the 1.5 million deaths
per year attributable to the disease occurring in developing countries. This disease is …

The scid mutation was backcrossed ten generations onto the NOD/Lt strain background,
resulting in an immunodeficient stock (NOD/LtSz-scid/scid) with multiple defects in adaptive …

Mycobacterium tuberculosis is one of the most ubiquitous pathogens in the world: estimates
are that roughly one third of the world's population is infected with the bacillus, and it is …

Rationale: Among patients with nontuberculous mycobacterial lung disease is a subset of
previously healthy women with a slender body morphotype, often with scoliosis and/or …

Several lines of evidence suggest that host genetic factors controlling the immune response
influence infection by Mycobacterium tuberculosis. The proinflammatory cytokine interleukin …

IFN-γ activates macrophages to kill diverse intracellular pathogens, but does not activate
human macrophages to kill virulent Mycobacterium tuberculosis. We tested the hypothesis …

Cytotoxic effector phenotype and function of MHC-restricted Mycobacterium tuberculosis
(MTB)-reactive CD4+ and CD8+ T lymphocytes were analyzed from healthy tuberculin skin …

During the past decade, the emphasis in the study of the pathogenesis of infectious
diseases has shifted from determining the functions of the cellular players in the …

Nontuberculous mycobacteria (NTM) are environmental microbes that cause a variety of
human diseases, particularly chronic lung infections. Despite the fact that NTM are …