A simple, primary amine bearing a C10H15 alkyl residue was found to display potent anti-
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …

Abstract α-Glucosidase is a key enzyme in hydrolysis of carbohydrates to glucose and
located in the small intestine brush border. Inhibition of this enzyme delay the release of …

Abstract Treatment of diabetes mellitus by oral α-glucosidase inhibitors is currently confined
to acarbose, miglitol and voglibose marred by efficacy problems and unwanted side effects …

Carbohydrates are important as signaling molecules and for cellular recognition events,
therefore offering scope for the development of carbohydrate-mimetic diagnostics and drug …

Glycosidases are extremely widespread enzymes responsible for the cleavage of glycosidic
bonds in glycoconjugates found in living organisms. Although it was well-known that the …

β-Glucosidase 2 (GBA2) is an enzyme that cleaves the membrane lipid glucosylceramide
into glucose and ceramide. The GBA2 gene is mutated in genetic neurological diseases …

In recent years, the function of pharmacological chaperones as a “thermodynamic stabilizer”
has been attracting attention in combination therapy. The coadministration of a …

Iminosugars are sugar analogues endowed with a high pharmacological potential. The wide
range of biological activities exhibited by these glycomimetics associated with their excellent …

A highly divergent route to lipophilic iminosugars that utilizes the thiol–ene reaction was
developed to enable the rapid synthesis of a collection of 16 dideoxyiminoxylitols bearing …

This review covers the literature in the past 15 years on glycosidase inhibitors lacking a
basic nitrogen (for example iminosugars/azasugars) with a focus on natural terpenoids, and …