Drug-repositioning approaches based on medical and life science databases

Y Zamami, H Hamano, T Niimura, F Aizawa… - Frontiers in …, 2021 - frontiersin.org
Drug repositioning is a drug discovery strategy in which an existing drug is utilized as a
therapeutic agent for a different disease. As information regarding the safety …

Forecasting gastric cancer diagnosis, prognosis, and drug repurposing with novel gene expression signatures

TY Demirtas, MR Rahman, MC Yurtsever… - OMICS: A Journal of …, 2022 - liebertpub.com
Gastric cancer (GC) is a prevalent disease worldwide with high mortality and poor treatment
success. Early diagnosis of GC and forecasting of its prognosis with the use of biomarkers …

Identification of potential inhibitors for drug resistance in acute lymphoblastic leukemia through differentially expressed gene analysis and in silico screening

B Özay, EY Tükel, GA Duran, Y Kiraz - Analytical Biochemistry, 2024 - Elsevier
Acute lymphoblastic leukemia (ALL) is a disease of lymphocyte origin predominantly
diagnosed in children. While its 5-year survival rate is high, resistance to chemotherapy …

Value analysis of ITLN1 in the diagnostic and prognostic assessment of colorectal cancer

Y Zhang, T Gao, M Wu, Z Xu… - Translational Cancer …, 2024 - pmc.ncbi.nlm.nih.gov
Background Colorectal cancer (CRC) remains the leading cause of cancer death worldwide.
Less than half of the patients are diagnosed when the cancer is locally advanced. Several …

Systems Biology and Human Diseases

R Jasmine, S Soundararajan, A Sherlin Rosita… - … Mechanisms of Complex …, 2024 - Springer
Abstract Systems biology is concerned with the analysis and modelling of complex
biological systems using computational and mathematical tools. This deals with the …