Microtubules and their role in cellular stress in cancer

AL Parker, M Kavallaris, JA McCarroll - Frontiers in oncology, 2014 - frontiersin.org
Microtubules are highly dynamic structures, which consist of α-and β-tubulin heterodimers,
and are involved in cell movement, intracellular trafficking, and mitosis. In the context of …

Heat shock proteins regulatory role in neurodevelopment

DJ Miller, PE Fort - Frontiers in neuroscience, 2018 - frontiersin.org
Heat shock proteins (Hsps) are a large family of molecular chaperones that are well-known
for their roles in protein maturation, re-folding and degradation. While some Hsps are …

GABAA-receptor-associated protein links GABAA receptors and the cytoskeleton

H Wang, FK Bedford, NJ Brandon, SJ Moss, RW Olsen - Nature, 1999 - nature.com
Type-A receptors for the neurotransmitter GABA (γ-aminobutyric acid) are ligand-gated
chloride channels that mediate inhibitory neurotransmission. Each subunit of the pentameric …

Heat shock proteins and cardiovascular pathophysiology

LHEH Snoeckx, RN Cornelussen… - Physiological …, 2001 - journals.physiology.org
In the eukaryotic cell an intrinsic mechanism is present providing the ability to defend itself
against external stressors from various sources. This defense mechanism probably evolved …

Molecular chaperones and the cytoskeleton

P Liang, TH MacRae - Journal of cell science, 1997 - journals.biologists.com
Heat shock proteins, first observed because they are preferentially synthesized by
organisms exposed to heat or other physiological stress, are also synthesized constitutively …

Heat shock protein 90 mediates macrophage activation by Taxol and bacterial lipopolysaccharide

CA Byrd, W Bornmann… - Proceedings of the …, 1999 - National Acad Sciences
Taxol, a plant-derived antitumor agent, stabilizes microtubules. Taxol also elicits cell signals
in a manner indistinguishable from bacterial lipopolysaccharide (LPS). LPS-like actions of …

Heat stress affects the organization of microtubules and cell division in Nicotiana tabacum cells

A Smertenko, P DRÁBER, V Viklický… - Plant, Cell & …, 1997 - Wiley Online Library
To investigate the effects of heat stress on the plant cytoskeleton, the structure of microtubule
arrays in N. tabacum suspension cells incubated at 38 or 42° C was analysed. Whilst …

[HTML][HTML] Expression of inducible Hsp70 enhances the proliferation of MCF-7 breast cancer cells and protects against the cytotoxic effects of hyperthermia

JA Barnes, DJ Dix, BW Collins, C Luft… - Cell stress & …, 2001 - ncbi.nlm.nih.gov
Heat shock proteins (Hsps) are ubiquitous proteins that are induced following exposure to
sublethal heat shock, are highly conserved during evolution, and protect cells from damage …

Two motifs within the tau microtubule‐binding domain mediate its association with the hsc70 molecular chaperone

M Sarkar, J Kuret, G Lee - Journal of neuroscience research, 2008 - Wiley Online Library
Tau, a microtubule‐associated protein with multiple phosphorylation sites, forms aggregates
that correlate with neurodegeneration in Alzheimer's disease and several other …

Microtubule-associated protein 1B, a growth-associated and phosphorylated scaffold protein

BM Riederer - Brain research bulletin, 2007 - Elsevier
Microtubule-associated protein 1B, MAP1B, is one of the major growth associated and
cytoskeletal proteins in neuronal and glial cells. It is present as a full length protein or may …