The structure of biologically active functionalized azoles: NMR spectroscopy and quantum chemistry

LI Larina - Magnetochemistry, 2022 - mdpi.com
This review summarizes the data on the stereochemical structure of functionalized azoles
(pyrazoles, imidazoles, triazoles, thiazoles, and benzazoles) and related compounds …

New thiazole and thiazole-chromene hybrids possessing morpholine units: Piperazine-mediated one-pot synthesis of potential acetylcholinesterase inhibitors

AEM Mekky, SMH Sanad… - Synthetic Communications, 2021 - Taylor & Francis
In the current study, new morpholine-linked thiazoles were prepared by the reaction of
salicylaldehyde derivative, thiosemicarbazide, and α-bromoketones. To mediate the …

Potential bacterial biofilm, MRSA, and DHFR inhibitors based on new morpholine-linked chromene-thiazole hybrids: One-pot synthesis and in silico study

SMH Sanad, AEM Mekky, TT El-Idreesy - Journal of Molecular Structure, 2022 - Elsevier
We report herein the utility of the morpholine-linked benzaldehyde as a key building block in
the preparation of two series of new chromene-thiazoles with potential bioactivities. In this …

Synthesis and antibacterial evaluation of new pyrido [3', 2': 4, 5] thieno [3, 2-d] pyrimidin-4 (3H)-one hybrids linked to different heteroarene units

SMH Sanad, AEM Mekky - Mendeleev Communications, 2021 - Elsevier
A three-component protocol involving the reaction of 3-aminothieno [2, 3-b] pyridine-2-
carboxylate, Me 2 NCH (OMe) 2 and heteroaryl (bis) amines in dioxane under microwave …

Regiodivergent Synthesis of 3,4- and 4,5-Disubstituted N-Methylpyrazoles from 4-Acyl-1H-pyrrole-2,3-dione and Methylhydrazine

J Poletto, MJV da Silva, KE Pianoski… - The Journal of …, 2022 - ACS Publications
A simple, efficient and highly regioselective method for the preparation of 3, 4-and 4, 5-
disubstituted N-methylpyrazoles in a one-pot procedure is reported. The methodology …

Effective synthesis of new benzo-fused macrocyclic and heteromacrocyclic bis (Schiff bases)

AAM Ahmed, AEM Mekky, SMH Sanad - Journal of the Iranian Chemical …, 2022 - Springer
In this study, the synthons 2-hydroxy-5-((arylthio) methyl) benzaldehydes were reacted with
1, ω-dihaloalkanes to produce the corresponding bis (aldehydes). The previous precursors …

Controlled Pyrazole-Hydrazone Annulation: Regiodivergent Synthesis of 1H- and 2H-Pyrazolo[3,4-d]pyridazinones

FA Rosa, AP Jacomini, MJ Vieira da Silva… - The Journal of …, 2023 - ACS Publications
An efficient and controlled site-selective annulation of 3, 5-diethoxycarbonyl 4-hydrazonyl
pyrazoles is described. The relative proportion of the products is affected by hydrazone …

A Review on Green Multicomponent Synthesis of Heterocyclic Compounds

A D'Souza, AS D'Souza, AP Mendonca… - International journal of …, 2022 - neliti.com
Heterocyclic compounds are of very much concern in our daily life. These 
compounds constitute the largest and most varied family of organic compounds …

Synthesis of 5-Chloro-3-styryl-1H-pyrazoles Based on 2,2-Dichlorovinyl Ketones

VA Kobelevskaya, SV Zinchenko, AV Popov - Russian Journal of Organic …, 2023 - Springer
Abstract The condensation of 4, 4-dichlorobut-3-en-2-one with aromatic aldehydes in the
presence of a catalytic amount of sulfuric acid afforded 1, 1-dichloro-5-(4-R-phenyl) penta-1 …

Synthesis and Characterization of 3-Methyl-1-(4-(trifluoromethyl)phenyl)indeno [1,2-c]pyrazol-4(1H)-one

L Lam, SH Park, J Sloop - Molbank, 2022 - mdpi.com
Pyrazoles have potential applications in the agrochemical and medicinal chemistry
industries as pesticides, anti-inflammatory medications, and antitumor drugs. Fluorinated …