The term 'field effect'(also known as field defect, field cancerization, or field carcinogenesis)
has been used to describe a field of cellular and molecular alteration, which predisposes to …

Comprehensive analysis of DNA methylation patterns is critical for understanding the
molecular basis of many human diseases. While hundreds of PCR-based DNA methylation …

DNA methylation is an important molecular modification that plays a key role in the
expression of cancer genes. Evaluation of epigenetic changes, hypomethylation and …

Cervical cancer (CC) is one of the most malignant tumors and the second or third most
common type of cancer in women worldwide. The association between human …

Background Promoter methylation of O6-methylguanine-DNA methyltransferase (MGMT) is
an important predictive biomarker in glioblastoma. The T variant of the MGMT promoter …

Simple Summary Multiple myeloma (MM) constitutes the second most common
hematological malignancy and is caused by aberrant plasma cell proliferation in the bone …

In recent decades, epidemiology, public health, and medical sciences have been
increasingly compartmentalized into narrower disciplines. The authors recognize the value …

Background Resistance of the highly aggressive glioblastoma multiforme (GBM) to drug
therapy is a major clinical problem resulting in a poor patient's prognosis. Beside promoter …

Clinical studies in patients with newly diagnosed glioblastoma treated with temozolomide
have shown that the methylation status of the O6-methylguanine-DNA methyltransferase …

Silencing of tumor suppressor genes by promoter hypermethylation is a key mechanism to
facilitate cancer progression in many malignancies. While promoter hypermethylation can …