Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial
MM Redfield, HH Chen, BA Borlaug, MJ Semigran… - Jama, 2013 - jamanetwork.com
Importance Studies in experimental and human heart failure suggest that
phosphodiesterase-5 inhibitors may enhance cardiovascular function and thus exercise …
phosphodiesterase-5 inhibitors may enhance cardiovascular function and thus exercise …
Current concepts on the reno-protective effects of phosphodiesterase 5 inhibitors in acute kidney injury: systematic search and review
Acute kidney injury (AKI) is associated with increased morbidity, prolonged hospitalization,
and mortality, especially in high risk patients. Phosphodiesterase 5 inhibitors (PDE5Is) …
and mortality, especially in high risk patients. Phosphodiesterase 5 inhibitors (PDE5Is) …
Phosphodiesterase 5 inhibition as a therapeutic target for ischemic stroke: a systematic review of preclinical studies
Abstract Phosphodiesterase 5 inhibitors (PDE5i), such as sildenafil (Viagra®) are widely
used for erectile dysfunction and pulmonary hypertension. Preclinical studies suggest that …
used for erectile dysfunction and pulmonary hypertension. Preclinical studies suggest that …
Sildenafil treatment attenuates lung and kidney injury due to overproduction of oxidant activity in a rat model of sepsis: a biochemical and histopathological study
Sepsis is a systemic inflammatory response to infection and a major cause of morbidity and
mortality. Sildenafil (SLD) is a selective and potent inhibitor of cyclic guanosine …
mortality. Sildenafil (SLD) is a selective and potent inhibitor of cyclic guanosine …
Sildenafil Prevents Podocyte Injury via PPAR-γ–Mediated TRPC6 Inhibition
R Sonneveld, JG Hoenderop, AM Isidori… - Journal of the …, 2017 - journals.lww.com
Transient receptor potential channel C6 (TRPC6) gain-of-function mutations and increased
TRPC6 expression in podocytes induce glomerular injury and proteinuria. Sildenafil reduces …
TRPC6 expression in podocytes induce glomerular injury and proteinuria. Sildenafil reduces …
Sildenafil activates antioxidant and antiapoptotic genes and inhibits proinflammatory cytokine genes in a rat model of renal ischemia/reperfusion injury
MH Zahran, AM Hussein, N Barakat, A Awadalla… - … urology and nephrology, 2015 - Springer
Objectives To study the possible renoprotective effect of sildenafil against renal
ischemia/reperfusion (I/R) injury and its effect on the expression of some antioxidant …
ischemia/reperfusion (I/R) injury and its effect on the expression of some antioxidant …
Sildenafil citrate for prophylaxis of nephropathy in an animal model of contrast-induced acute kidney injury
DA Lauver, EG Carey, IL Bergin, BR Lucchesi… - PLoS …, 2014 - journals.plos.org
Contrast-induced acute kidney injury (CIAKI) is one of the commonest complications
associated with contrast media (CM). Although the exact etiology of CIAKI remains unclear …
associated with contrast media (CM). Although the exact etiology of CIAKI remains unclear …
The effects of PDE5 inhibitory drugs on renal ischemia/reperfusion injury in rats
The aim of the present study was to evaluate the effects of phosphodiesterase type 5 (PDE5)
inhibitory drugs, Tadalafil and Sildenafil, on inducible NOS (iNOS), endothelial NOS (eNOS) …
inhibitory drugs, Tadalafil and Sildenafil, on inducible NOS (iNOS), endothelial NOS (eNOS) …
Phosphodiesterase-5 inhibition attenuates early renal ischemia-reperfusion-induced acute kidney injury: assessment by quantitative measurement of urinary NGAL …
R Sohotnik, O Nativ, A Abbasi… - American journal …, 2013 - journals.physiology.org
Acute kidney injury (AKI) is a common clinical problem that still lacks effective treatment.
Phosphodiesterase-5 (PDE5) inhibitors possess anti-apoptotic and anti-oxidant properties …
Phosphodiesterase-5 (PDE5) inhibitors possess anti-apoptotic and anti-oxidant properties …
Sildenafil obviates ischemia-reperfusion injury–induced acute kidney injury through peroxisome proliferator–activated receptor γ agonism in rats
Background Sildenafil is a phosphodiesterase inhibitor used clinically for treating erectile
dysfunction. Few studies suggest sildenafil to be a renoprotective agent. The present study …
dysfunction. Few studies suggest sildenafil to be a renoprotective agent. The present study …