Single-cell genomic technologies are revealing the cellular composition, identities and
states in tissues at unprecedented resolution. They have now scaled to the point that it is …

Human pluripotent stem (hPS) cells can, in theory, be differentiated into any cell type,
making them a powerful in vitro model for human biology. Recent technological advances …

Interindividual genetic variation affects the susceptibility to and progression of many
diseases,. However, efforts to study how individual human brains differ in normal …

Induced pluripotent stem cells (iPSCs) are valuable in disease modeling because of their
potential to expand and differentiate into virtually any cell type and recapitulate key aspects …

Communication between the immune and the nervous system is essential for human brain
development and homeostasis. Disruption of this intricately regulated crosstalk can lead to …

Existing therapies for type 2 diabetes mellitus (T2DM) show limited efficacy or have adverse
effects. Numerous genetic variants associated with T2DM have been identified, but progress …

Expression quantitative trait loci (eQTLs) provide a key bridge between noncoding DNA
sequence variants and organismal traits. The effects of eQTLs can differ among tissues, cell …

Most cases of Alzheimer's disease (AD) are late-onset dementias (LOAD). However,
research on AD is predominantly of early-onset disease (EOAD). The determinants of EOAD …

The prenatal environment can alter neurodevelopmental and clinical trajectories, markedly
increasing risk for psychiatric disorders in childhood and adolescence. To understand if and …

En masse phenotyping technology, using massively mosaic donor-derived cells and
organoids, can offer enriched insights for cellotype–phenotype association in a cell-type …