Prevention of cancer through immunization: Prospects and challenges for the 21st century

IH Frazer, DR Lowy, JT Schiller - European journal of …, 2007 - Wiley Online Library
Persistent infection by several microbial agents is responsible for at least 15% of cancer
globally, including most cancers of the liver, stomach, and cervix. The recent development of …

Hepatitis C virus envelope glycoprotein immunization of rodents elicits cross-reactive neutralizing antibodies

Z Stamataki, S Coates, MJ Evans, M Wininger… - Vaccine, 2007 - Elsevier
Neutralizing antibody responses elicited during infection generally confer protection from
infection. Hepatitis C virus (HCV) encodes two glycoproteins E1 and E2 that are essential for …

Production and immunogenicity of different prophylactic vaccines for hepatitis C virus

Q Zhao, K He, X Zhang, M Xu… - Experimental and …, 2022 - spandidos-publications.com
Hepatitis C virus (HCV) infection is a global health challenge, and prophylactic vaccines are
the most effective way to eliminate the infection. To date, numerous forms of preventive …

Protective T cell and antibody immune responses against hepatitis C virus achieved using a biopolyester-bead-based vaccine delivery system

G Martínez-Donato, B Piniella, D Aguilar… - Clinical and Vaccine …, 2016 - Am Soc Microbiol
Hepatitis C virus (HCV) infection is a major worldwide problem. Chronic hepatitis C is
recognized as one of the major causes of cirrhosis, hepatocellular carcinoma, and liver …

Blocking hepatitis C virus infection with recombinant form of envelope protein 2 ectodomain

J Whidby, G Mateu, H Scarborough, B Demeler… - Journal of …, 2009 - Am Soc Microbiol
More than 120 million people worldwide are chronically infected with hepatitis C virus
(HCV), making HCV infection the leading cause of liver transplantation in developed …

Protective cellular immune response against hepatitis C virus elicited by chimeric protein formulations in BALB/c mice

S Olivera, A Perez, V Falcon, D Urquiza, D Pichardo… - Archives of …, 2020 - Springer
The eradication of hepatitis C virus (HCV) infection is a public health priority. Despite the
efficiency of treatment with direct-acting antivirals, the high cost of the therapy and the lack of …

Identification of a novel drug lead that inhibits HCV infection and cell-to-cell transmission by targeting the HCV E2 glycoprotein

RR Al Olaby, L Cocquerel, A Zemla, L Saas… - PloS one, 2014 - journals.plos.org
Hepatitis C Virus (HCV) infects 200 million individuals worldwide. Although several FDA
approved drugs targeting the HCV serine protease and polymerase have shown promising …

[HTML][HTML] Expression, purification and immunogenic description of a hepatitis C virus recombinant CoreE1E2 protein expressed by yeast Pichia pastoris

M Fazlalipour, H Keyvani, SHR Monavari… - Jundishapur Journal of …, 2015 - ncbi.nlm.nih.gov
Background: Gradual development of a useful vaccine can be the main point in the control
and eradication of Hepatitis C virus (HCV) infection. Hepatitis C Virus envelope …

Expression and processing of hepatitis C virus structural proteins in Pichia pastoris yeast

G Martinez-Donato, N Acosta-Rivero… - Biochemical and …, 2006 - Elsevier
Development of heterologous systems to produce useful HCV vaccine candidates is an
important part of HCV research. In this study different HCV structural region variants were …

Conserved peptides within the E2 region of Hepatitis C virus induce humoral and cellular responses in goats

MK El-Awady, AA Tabll, YS El-Abd, H Yousif, M Hegab… - Virology Journal, 2009 - Springer
The reason (s) why human antibodies raised against hepatitis C virus (HCV) E2 epitopes do
not offer protection against multiple viral infections may be related to either genetic …