Infections associated with immunotherapeutic and molecular targeted agents in hematology and oncology. A position paper by the European Conference on Infections …

G Maschmeyer, J De Greef, SC Mellinghoff, A Nosari… - Leukemia, 2019 - nature.com
A multitude of new agents for the treatment of hematologic malignancies has been
introduced over the past decade. Hematologists, infectious disease specialists, stem cell …

Infectious complications of biological and small molecule targeted immunomodulatory therapies

JS Davis, D Ferreira, E Paige, C Gedye… - Clinical microbiology …, 2020 - Am Soc Microbiol
The past 2 decades have seen a revolution in our approach to therapeutic
immunosuppression. We have moved from relying on broadly active traditional medications …

Antibody responses after first and second Covid-19 vaccination in patients with chronic lymphocytic leukaemia

H Parry, G McIlroy, R Bruton, M Ali, C Stephens… - Blood cancer …, 2021 - nature.com
B-cell chronic lymphocytic leukaemia (CLL) is associated with immunosuppression and
patients are at increased clinical risk following SARS-CoV-2 infection. Covid-19 vaccines …

Vaccination of patients with haematological malignancies who did not have transplantations: guidelines from the 2017 European Conference on Infections in …

M Mikulska, S Cesaro, H de Lavallade… - The Lancet Infectious …, 2019 - thelancet.com
Patients with haematological malignancies are at high risk of infection because of various
mechanisms of humoral and cell-mediated immune deficiencies, which mainly depend on …

BTK inhibitors in chronic lymphocytic leukemia: biological activity and immune effects

M Palma, TA Mulder, A Österborg - Frontiers in immunology, 2021 - frontiersin.org
Bruton´ s tyrosine kinase (BTK) inhibitor (BTKi) s block the B-cell receptor (BCR) signaling
cascade by binding to the BTK enzyme preventing the proliferation and survival of malignant …

Poor neutralizing antibody responses in 106 patients with WM after vaccination against SARS-CoV-2: a prospective study

M Gavriatopoulou, E Terpos… - Blood …, 2021 - ashpublications.org
Immunocompromised patients with hematologic malignancies are more susceptible to
COVID-19 and at higher risk of severe complications and worse outcomes compared with …

Response to the conjugate pneumococcal vaccine (PCV13) in patients with chronic lymphocytic leukemia (CLL)

FR Mauro, D Giannarelli, CM Galluzzo, C Vitale… - Leukemia, 2021 - nature.com
Pneumococcal (PC) vaccination is recommended for patients with chronic lymphocytic
leukemia (CLL). However, response to vaccines has been investigated in a small series of …

Poor neutralizing antibody responses in 132 patients with CLL, NHL and HL after vaccination against SARS-CoV-2: a prospective study

E Terpos, M Gavriatopoulou, D Fotiou, C Giatra… - Cancers, 2021 - mdpi.com
Simple Summary The urgency of the COVID-19 pandemic has led to accelerated vaccine
development within less than a year. Emerging data suggest that the ability of patients with …

Immune dysfunction in patients with chronic lymphocytic leukemia and challenges during COVID-19 pandemic

P Langerbeins, B Eichhorst - Acta haematologica, 2021 - karger.com
The novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) has been first
described in December 2019 in Wuhan, China, and has led to a worldwide pandemic ever …

Infections in patients with chronic lymphocytic leukaemia: mitigating risk in the era of targeted therapies

BW Teh, CS Tam, S Handunnetti, LJ Worth, MA Slavin - Blood reviews, 2018 - Elsevier
Chronic lymphocytic leukaemia (CLL) is the most common leukaemia with infections a
leading cause of morbidity and mortality. Recently there has been a paradigm shift from the …