Diabetic nephropathy (DN) is the leading cause of end‐stage renal disease worldwide.
Chronic hyperglycemia and high blood pressure are the main risk factors for the …

Diabetes is one of the leading causes of kidney disease. Diabetic kidney disease (DKD) is a
major cause of end-stage kidney disease (ESKD) worldwide, and it is linked to an increase …

The renin-angiotensin system (RAS) constitutes a key hormonal system in the physiological
regulation of blood pressure through peripheral and central mechanisms. Indeed …

Diabetic nephropathy is a leading cause of end-stage renal failure worldwide. Its
morphologic characteristics include glomerular hypertrophy, basement membrane …

Diabetic nephropathy is a well-known complication of diabetes and is a leading cause of
chronic renal failure in the Western world. It is characterized by the accumulation of …

Diabetic nephropathy is characterized by excessive amassing of extracellular matrix (ECM)
with thickening of glomerular and tubular basement membranes and increased amount of …

Diabetes mellitus is known to trigger retinopathy, neuropathy and nephropathy. Diabetic
nephropathy, a long-term major microvascular complication of uncontrolled hyperglycemia …

Renal fibrosis is the usual outcome of an excessive accumulation of extracellular matrix
(ECM) that frequently occurs in membranous and diabetic nephropathy. The result of renal …

Although debated for many years whether haemodynamic or structural changes are more
important in the development of diabetic nephropathy, it is now clear that these processes …

Hyperglycemia/oxidative stress has been implicated in the initiation and progression of
diabetic complications while the components of Keap1/Nrf2/ARE signaling are being …