Abstract N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …

Endogenous bioactive lipids are part of a complex network that modulates a plethora of
cellular and molecular processes involved in health and disease, of which inflammation …

Apart from having been used and misused for at least four millennia for, among others,
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …

The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

Excess intra-abdominal adipose tissue accumulation, often termed visceral obesity, is part of
a phenotype including dysfunctional subcutaneous adipose tissue expansion and ectopic …

The CB 1 and CB 2 cannabinoid receptors (CB 1 R, CB 2 R) are members of the G protein-
coupled receptor (GPCR) family that were identified over 20 years ago. CB 1 Rs and CB 2 …

Obesity is associated with metabolic alterations related to glucose homeostasis and
cardiovascular risk factors. These metabolic alterations are associated with low-grade …

Various metabolic disorders are associated with changes in inflammatory tone. Among the
latest advances in the metabolism field, the discovery that gut microorganisms have a major …

Endocannabinoids and cannabinoid CB1 receptors are known to play a generalized role in
energy homeostasis. However, clinical trials with the first generation of CB1 blockers, now …

Obesity is characterised by altered gut microbiota, low‐grade inflammation and increased
endocannabinoid (eCB) system tone; however, a clear connection between gut microbiota …