Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
Structure, function, and allosteric modulation of NMDA receptors
NMDA-type glutamate receptors are ligand-gated ion channels that mediate a Ca2+-
permeable component of excitatory neurotransmission in the central nervous system (CNS) …
permeable component of excitatory neurotransmission in the central nervous system (CNS) …
Therapeutic potential of N-methyl-D-aspartate receptor modulators in psychiatry
Abstract N-methyl-D-aspartate (NMDA) receptors mediate a slow component of excitatory
synaptic transmission, are widely distributed throughout the central nervous system, and …
synaptic transmission, are widely distributed throughout the central nervous system, and …
Merging signaling with structure: functions and mechanisms of plant glutamate receptor ion channels
AA Simon, C Navarro-Retamal… - Annual Review of Plant …, 2023 - annualreviews.org
Plant glutamate receptor-like (GLR) genes encode ion channels with demonstrated roles in
electrical and calcium (Ca2+) signaling. The expansion of the GLR family along the lineage …
electrical and calcium (Ca2+) signaling. The expansion of the GLR family along the lineage …
[HTML][HTML] Opening of glutamate receptor channel to subconductance levels
MV Yelshanskaya, DS Patel, CM Kottke, MG Kurnikova… - Nature, 2022 - nature.com
Ionotropic glutamate receptors (iGluRs) are tetrameric ligand-gated ion channels that open
their pores in response to binding of the agonist glutamate,–. An ionic current through a …
their pores in response to binding of the agonist glutamate,–. An ionic current through a …
Modulation of GluA2–γ5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2
SP Gangwar, LY Yen, MV Yelshanskaya… - Nature Structural & …, 2023 - nature.com
Synaptic complexes of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)
receptors (AMPARs) with auxiliary subunits mediate most excitatory neurotransmission and …
receptors (AMPARs) with auxiliary subunits mediate most excitatory neurotransmission and …
Subsynaptic positioning of AMPARs by LRRTM2 controls synaptic strength
Recent evidence suggests that nano-organization of proteins within synapses may control
the strength of communication between neurons in the brain. The unique subsynaptic …
the strength of communication between neurons in the brain. The unique subsynaptic …
Cryo-EM structure of a mitochondrial calcium uniporter
Calcium transport plays an important role in regulating mitochondrial physiology and
pathophysiology. The mitochondrial calcium uniporter (MCU) is a calcium-selective ion …
pathophysiology. The mitochondrial calcium uniporter (MCU) is a calcium-selective ion …
Mechanisms of channel block in calcium-permeable AMPA receptors
AMPA receptors mediate fast excitatory neurotransmission and are critical for CNS
development and function. Calcium-permeable subsets of AMPA receptors are strongly …
development and function. Calcium-permeable subsets of AMPA receptors are strongly …
Identification and functional evaluation of GRIA1 missense and truncation variants in individuals with ID: An emerging neurodevelopmental syndrome
V Ismail, LG Zachariassen, A Godwin… - The American Journal of …, 2022 - cell.com
GRIA1 encodes the GluA1 subunit of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate
(AMPA) receptors, which are ligand-gated ion channels that act as excitatory receptors for …
(AMPA) receptors, which are ligand-gated ion channels that act as excitatory receptors for …