[HTML][HTML] Coronavirus RNA proofreading: molecular basis and therapeutic targeting

F Robson, KS Khan, TK Le, C Paris, S Demirbag… - Molecular cell, 2020 - cell.com
Summary The coronavirus disease 2019 (COVID-19) that is wreaking havoc on worldwide
public health and economies has heightened awareness about the lack of effective antiviral …

Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug design

B Malone, N Urakova, EJ Snijder… - … Reviews Molecular Cell …, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has killed millions of
people and continues to cause massive global upheaval. Coronaviruses are positive-strand …

Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label …

CC Butler, FDR Hobbs, OA Gbinigie, NM Rahman… - The Lancet, 2023 - thelancet.com
Background The safety, effectiveness, and cost-effectiveness of molnupiravir, an oral
antiviral medication for SARS-CoV-2, has not been established in vaccinated patients in the …

Molnupiravir for oral treatment of Covid-19 in nonhospitalized patients

A Jayk Bernal, MM Gomes da Silva… - … England Journal of …, 2022 - Mass Medical Soc
Background New treatments are needed to reduce the risk of progression of coronavirus
disease 2019 (Covid-19). Molnupiravir is an oral, small-molecule antiviral prodrug that is …

Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis

F Kabinger, C Stiller, J Schmitzová… - Nature structural & …, 2021 - nature.com
Molnupiravir is an orally available antiviral drug candidate currently in phase III trials for the
treatment of patients with COVID-19. Molnupiravir increases the frequency of viral RNA …

Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2

DC Schultz, RM Johnson, K Ayyanathan, J Miller… - Nature, 2022 - nature.com
The SARS-CoV-2 virus has infected more than 261 million people and has led to more than
5 million deaths in the past year and a half (https://www. who. org/). Individuals with SARS …

[HTML][HTML] Therapeutically administered ribonucleoside analogue MK-4482/EIDD-2801 blocks SARS-CoV-2 transmission in ferrets

RM Cox, JD Wolf, RK Plemper - Nature microbiology, 2021 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic is having a catastrophic
impact on human health 1. Widespread community transmission has triggered stringent …

Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template

CJ Gordon, EP Tchesnokov, RF Schinazi… - Journal of Biological …, 2021 - ASBMB
The RNA-dependent RNA polymerase of the severe acute respiratory syndrome coronavirus
2 is an important target in current drug development efforts for the treatment of coronavirus …

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

TP Sheahan, AC Sims, S Zhou, RL Graham… - Science translational …, 2020 - science.org
Coronaviruses (CoVs) traffic frequently between species resulting in novel disease
outbreaks, most recently exemplified by the newly emerged SARS-CoV-2, the causative …

[HTML][HTML] Molnupiravir: coding for catastrophe

B Malone, EA Campbell - Nature Structural & Molecular Biology, 2021 - nature.com
Molnupiravir, a wide-spectrum antiviral that is currently in phase 2/3 clinical trials for the
treatment of COVID-19, is proposed to inhibit viral replication by a mechanism known as …