Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A Genotypes and Serotonin …
CA Bousman, JM Stevenson… - Clinical …, 2023 - Wiley Online Library
Serotonin reuptake inhibitor antidepressants, including selective serotonin reuptake
inhibitors (SSRIs; ie, citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and …
inhibitors (SSRIs; ie, citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and …
[HTML][HTML] Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation
Cytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …
Prediction of CYP2D6 phenotype from genotype across world populations
A Gaedigk, K Sangkuhl, M Whirl-Carrillo, T Klein… - Genetics in …, 2017 - nature.com
Purpose: Owing to its highly polymorphic nature and major contribution to the metabolism
and bioactivation of numerous clinically used drugs, CYP2D6 is one of the most extensively …
and bioactivation of numerous clinically used drugs, CYP2D6 is one of the most extensively …
PharmVar GeneFocus: CYP2D6
C Nofziger, AJ Turner, K Sangkuhl… - Clinical …, 2020 - Wiley Online Library
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly
polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism …
polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism …
[HTML][HTML] Recommendations for clinical CYP2D6 genotyping allele selection: a joint consensus recommendation of the Association for Molecular Pathology, College of …
VM Pratt, LH Cavallari, AL Del Tredici… - The Journal of Molecular …, 2021 - Elsevier
The goals of the Association for Molecular Pathology Clinical Practice Committee's
Pharmacogenomics (PGx) Working Group are to define the key attributes of …
Pharmacogenomics (PGx) Working Group are to define the key attributes of …
Complexities of CYP2D6 gene analysis and interpretation
A Gaedigk - International review of psychiatry, 2013 - Taylor & Francis
Abstract Cytochrome P450 2D6 (CYP2D6) plays an important role in the metabolism and
bioactivation of about 25% of clinically used drugs including many antidepressants …
bioactivation of about 25% of clinically used drugs including many antidepressants …
Pharmacogenomics of CYP2D6: molecular genetics, interethnic differences and clinical importance
LK Teh, L Bertilsson - Drug metabolism and pharmacokinetics, 2012 - jstage.jst.go.jp
CYP2D6 has received intense attention since the beginning of the pharmacogenetic era in
the 1970s. This is because of its involvement in the metabolism of more than 25% of the …
the 1970s. This is because of its involvement in the metabolism of more than 25% of the …
PharmVar Tutorial on CYP2D6 Structural Variation Testing and Recommendations on Reporting
AJ Turner, C Nofziger, BE Ramey, RC Ly… - Clinical …, 2023 - Wiley Online Library
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly
polymorphic human CYP2D6 gene locus and a comprehensive summary of structural …
polymorphic human CYP2D6 gene locus and a comprehensive summary of structural …
Challenges in CYP2D6 phenotype assignment from genotype data: a critical assessment and call for standardization
J Kevin Hicks, JJ Swen, A Gaedigk - Current drug metabolism, 2014 - ingentaconnect.com
The cytochrome P450 2D6 (CYP2D6) enzyme contributes to the metabolism and/or
bioactivation of approximately 25% of clinically used drugs. The CYP2D6 gene locus is …
bioactivation of approximately 25% of clinically used drugs. The CYP2D6 gene locus is …
Sequencing the CYP2D6 Gene: From Variant Allele Discovery to Clinical Pharmacogenetic Testing
CYP2D6 is one of the most studied enzymes in the field of pharmacogenetics. The CYP2D6
gene is highly polymorphic with over 100 catalogued star (*) alleles, and clinical CYP2D6 …
gene is highly polymorphic with over 100 catalogued star (*) alleles, and clinical CYP2D6 …