Age-related macular degeneration (AMD) is the leading cause of blindness in individuals
over the age of 50 years, yet its etiology and pathogenesis largely remain uncovered. Single …

Alzheimer's disease (AD) is a multifaceted neurodegenerative condition marked by gradual
cognitive deterioration and the loss of neurons. While conventional bulk RNA sequencing …

Transcriptome analysis of individual cells by single-cell RNA-seq (scRNA-seq) has become
routine for eukaryotic tissues, even being applied to whole multicellular organisms. In …

The development of systems biology represents an immense breakthrough in our ability to
perform translational research and deliver personalized and precision medicine. A …

Mitochondria, the cellular powerhouses, possess their own unique genetic system, including
replication, transcription, and translation. Studying these processes is crucial for …

Throughout its history, humanity has been exposed to various diseases. As human society
evolved, the incidence and prevalence of communicable and non-communicable diseases …

On the RNA level, viral infections are characterized by perturbations in the host cell
transcriptome as well as the development of viral genetic information. Investigating the …

Recent advancements in single-cell and spatial omics technologies have revolutionized our
ability to capture multiple modalities data at a genome-wide scale within individual cells …

Single cell spatial-omics data visualization plays a pivotal role in unraveling the intricate
spatial organization and heterogeneity of cellular systems. Although various software tools …

Diet-induced maternal obesity impacts feto-placental growth and induces sex-specific
alterations in placental morphology, mitochondrial bioenergetics, dynamics, lipid …