The tumour microenvironment is the primary location in which tumour cells and the host
immune system interact. Different immune cell subsets are recruited into the tumour …

Gloss PD-L1 and PD-1 (PD) pathway blockade is a highly promising therapy and has
elicited durable antitumor responses and long-term remissions in a subset of patients with a …

Chemokines are a large family of small chemotactic cytokines that coordinates immune cell
trafficking. In cancer, they have a pivotal role in the migration pattern of immune cells into the …

Increasing evidence indicates that the tumor microenvironment has critical roles in all
aspects of cancer biology, including growth, angiogenesis, metastasis and progression …

Solid tumors consist of neoplastic cells, non-malignant stromal cells, and migratory
hematopoietic cells. Complex interactions between the cell types in this microenvironment …

Chemokines are chemotactic cytokines that promote cancer growth, metastasis, and
regulate resistance to chemotherapy. Stromal cell-derived factor 1 (SDF1) also known as …

Mononuclear phagocytes are versatile cells that can express different functional programs in
response to microenvironmental signals. Fully polarized M1 and M2 (or alternatively …

Chemokines, small pro-inflammatory chemoattractant cytokines that bind to specific G-
protein-coupled seven-span transmembrane receptors, are major regulators of cell …

A complex network of chemokines and their receptors influences the development of primary
tumours and metastases. New information about the biological role of chemokines in these …

Chemokines play a vital role in tumor progression and metastasis. Chemokines are involved
in the growth of many cancers including breast cancer, ovarian cancer, pancreatic cancer …