Lysosomes are membrane-bound organelles with roles in processes involved in degrading
and recycling cellular waste, cellular signalling and energy metabolism. Defects in genes …

Macroautophagy/autophagy is an evolutionarily conserved pathway responsible for clearing
cytosolic aggregated proteins, damaged organelles or invading microorganisms …

Cells rely on surveillance systems such as autophagy to handle protein alterations and
organelle damage. Dysfunctional autophagy, an evolutionarily conserved cellular …

Parkinson disease (PD) treatment options have conventionally focused on dopamine
replacement and provision of symptomatic relief. Current treatments cause undesirable …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Alzheimer's disease (AD) is one of the biggest human health threats due to increases in
aging of the global population. Unfortunately, drugs for treating AD have been largely …

Cells have developed elaborate quality-control mechanisms for proteins and organelles to
maintain cellular homeostasis. Such quality-control mechanisms are maintained by …

Autophagy is an important cellular self-digestion and recycling pathway that helps in
maintaining cellular homeostasis. Dysregulation at various steps of the autophagic and …

Parkinson's disease (PD) is one of the most debilitating brain diseases. Despite the
availability of symptomatic treatments, response towards the health of PD patients remains …

Selective autophagy is an evolutionarily conserved mechanism that removes excess protein
aggregates and damaged intracellular components. Most eukaryotic cells, including …