Epstein Barr virus: development of vaccines and immune cell therapy for EBV-associated diseases

X Cui, CM Snapper - Frontiers in Immunology, 2021 - frontiersin.org
Epstein-Barr virus (EBV) is the first human tumor virus discovered and is strongly implicated
in the etiology of multiple lymphoid and epithelial cancers. Each year EBV associated …

EBV-associated diseases: Current therapeutics and emerging technologies

S Chakravorty, B Afzali, M Kazemian - Frontiers in Immunology, 2022 - frontiersin.org
EBV is a prevalent virus, infecting> 90% of the world's population. This is an oncogenic virus
that causes~ 200,000 cancer-related deaths annually. It is, in addition, a significant …

Epstein‐Barr virus in systemic autoimmune diseases

AH Draborg, K Duus, G Houen - Journal of Immunology …, 2013 - Wiley Online Library
Systemic autoimmune diseases (SADs) are a group of connective tissue diseases with
diverse, yet overlapping, symptoms and autoantibody development. The etiology behind …

[HTML][HTML] Spontaneous lytic replication and epitheliotropism define an Epstein-Barr virus strain found in carcinomas

MH Tsai, A Raykova, O Klinke, K Bernhardt, K Gärtner… - Cell reports, 2013 - cell.com
Summary The Epstein-Barr virus (EBV) is found in a variety of tumors whose incidence
greatly varies around the world. A poorly explored hypothesis is that particular EBV strains …

A new model of Epstein-Barr virus infection reveals an important role for early lytic viral protein expression in the development of lymphomas

SD Ma, S Hegde, KH Young, R Sullivan… - Journal of …, 2011 - Am Soc Microbiol
Epstein-Barr virus (EBV) infects cells in latent or lytic forms, but the role of lytic infection in
EBV-induced lymphomas is unclear. Here, we have used a new humanized mouse model …

Epstein-Barr virus entry

LM Hutt-Fletcher - Journal of virology, 2007 - Am Soc Microbiol
One of the many conundrums of herpesvirology is why a herpesvirus is so proffigate in its
use of four or more envelope glycoproteins for entry into a cell when other viruses can …

Neuropilin 1 is an entry factor that promotes EBV infection of nasopharyngeal epithelial cells

HB Wang, H Zhang, JP Zhang, Y Li, B Zhao… - Nature …, 2015 - nature.com
Epstein–Barr virus (EBV) is implicated as an aetiological factor in B lymphomas and
nasopharyngeal carcinoma. The mechanisms of cell-free EBV infection of nasopharyngeal …

Epstein-Barr virus latent membrane protein 2A is a B-cell receptor mimic and essential for B-cell survival

C Mancao, W Hammerschmidt - Blood, The Journal of the …, 2007 - ashpublications.org
Many cells latently infected with Epstein-Barr virus (EBV), including certain virus-associated
tumors, express latent membrane protein 2A (LMP2A), suggesting an important role for this …

An antibody targeting the fusion machinery neutralizes dual-tropic infection and defines a site of vulnerability on Epstein-Barr virus

J Snijder, MS Ortego, C Weidle, AB Stuart, MD Gray… - Immunity, 2018 - cell.com
Epstein-Barr virus (EBV) is a causative agent of infectious mononucleosis and is associated
with 200,000 new cases of cancer and 140,000 deaths annually. Subunit vaccines against …

Micro RNAs of Epstein-Barr virus promote cell cycle progression and prevent apoptosis of primary human B cells

E Seto, A Moosmann, S Grömminger, N Walz… - PLoS …, 2010 - journals.plos.org
Cellular and viral microRNAs (miRNAs) are involved in many different processes of key
importance and more than 10,000 miRNAs have been identified so far. In general, relatively …