Peptides have the potential to be potent pharmaceutical agents for the treatment of many
central nervous system derived maladies. Unfortunately peptides are generally water …

Despite the omnipresence of protein glycosylation in nature, little is known about how the
attachment of carbohydrates affects peptide and protein activity. One reason is the lack of a …

The thesis of this innovative and challenging book, first published in 2001, is that brain drug
development has been restricted by the failure of adequate brain drug targeting, and that …

The brain is protected and isolated from the general circulation by a highly efficient blood-
brain barrier. This is characterised by relatively impermeable endothelial cells with tight …

The synthesis of 18 N-α-FMOC-amino acid glycosides for solid-phase glycopeptide
assembly is reported. The glycosides were synthesized either from the corresponding …

Peptides are an important class of molecules with diverse biological activities. Many
endogenous peptides, especially neuropeptides and peptide hormones, play critical roles in …

Endogenous peptides (eg enkephalins) control many aspects of brain function, cognition,
and perception. The use of these neuroactive peptides in diverse studies has led to an …

Despite various advantages, opioid peptides have been limited in their therapeutic uses due
to the main drawbacks in metabolic stability, blood-brain barrier permeability, and …

Peptides are key regulators in cellular and intercellular physiological responses and
possess enormous promise for the treatment of pathological conditions. Opioid peptide …

The blood–brain barrier prevents the entry of many potentially therapeutic peptide drugs to
the brain. Glycosylation has shown potential as a methodology for improving delivery to the …