Abstract Structure‐based ligand design in medicinal chemistry and crop protection relies on
the identification and quantification of weak noncovalent interactions and understanding the …

Fluorine substituents have become a widespread and important drug component, their
introduction facilitated by the development of safe and selective fluorinating agents …

Intermolecular interactions involving aromatic rings are key processes in both chemical and
biological recognition. Their understanding is essential for rational drug design and lead …

Ever since the first automated de novo design techniques were conceived only 15 years
ago, the computer-based design of hit and lead structure candidates has emerged as a …

The influence of a xenobiotic compound on an organism is usually summarized by the
expression biological activity. If a controlled, therapeutically relevant, and regulatory action …

Multi-component reactions (MCRs) enable the facile, automated and high throughput
generation of small organic molecules. MCRs have been used to create diversity oriented …

The clinical syndromes of thromboembolism are evoked by an excessive stimulation of the
coagulation cascade. In this context, the serine protease thrombin plays a key role …

Why does experimental determination of the structure of drug–receptor complexes so often
result in surprises? The importance of hydrogen bonding and hydrophobic interactions in …

Abstract Zwischenmolekulare Wechselwirkungen unter Beteiligung aromatischer Ringe sind
Schlüsselvorgänge sowohl in chemischen als auch in biologischen Erkennungsprozessen …

Although fluorination of pharmacologically active compounds has long been a common
strategy to increase their metabolic stability and membrane permeation, the functionality of …