IL-17 is a highly versatile pro-inflammatory cytokine crucial for a variety of processes,
including host defense, tissue repair, the pathogenesis of inflammatory disease and the …

Despite the large number of immunomodulatory or immunosuppressive treatments available
to treat relapsing–remitting multiple sclerosis (MS), treatment of the progressive phase of the …

Oligodendrocyte precursor cells (OPCs) are abundant in the adult central nervous system,
and have the capacity to regenerate oligodendrocytes and myelin. However, in inflammatory …

Remyelination failure contributes to axonal loss and progression of disability in multiple
sclerosis. The failed repair process could be due to ongoing toxic neuroinflammation and to …

The IL-17 family is an evolutionarily old cytokine family consisting of six members (IL-17A
through IL-17F). IL-17 family cytokines signal through heterodimeric receptors that include …

The interleukin-(IL-) 17 family of cytokines is composed of six members named IL-17A, IL-
17B, IL-17C, IL-17D, IL-17E, and IL-17F. IL-17A is the prototype of this family, and it was the …

Richter's transformation (RT) is an aggressive lymphoma that occurs upon progression from
chronic lymphocytic leukemia (CLL). Transformation has been associated with genetic …

Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system
(CNS) and the most common non-traumatic cause of neurological disability in young adults …

Remyelination failure in multiple sclerosis (MS) contributes to progression of disability. The
deficient repair results from neuroinflammation and deposition of inhibitors including …

The immune system's role is much more than merely recognizing self vs. non-self and
involves maintaining homeostasis and integrity of the organism starting from early …