The increasing prevalence of antibiotic-resistant bacteria portends an impending
postantibiotic age, characterized by diminishing efficacy of common antibiotics and routine …

Conspectus Glycosaminoglycans (GAGs) are a family of structurally complex
heteropolysaccharides composed of alternating hexosamine and uronic acid or galatose …

The introduction of unnatural chemical moieties into glycosaminoglycans (GAGs) has
enormous potential to facilitate studies of the mechanism and application of these critical …

The study of cellular glycosylation presents many challenges due, in large part, to the
nontemplated nature of glycan biosynthesis and glycans' structural complexity …

Chondroitin and heparosan, important polysaccharides and key precursors of chondroitin
sulfate and heparin/heparan sulfate, have drawn much attention due to their wide …

Glycosaminoglycans (GAGs) are naturally occurring acidic polysaccharides with wide
applications in pharmaceuticals, cosmetics, and health foods. The diverse biological …

Heparin is a naturally occurring glycosaminoglycan isolated from animal tissues and is
medically used as an anticoagulant drug. Adulteration attempts of isolated heparin with …

Heparin is one of the most widely used natural drugs, and has been the preferred
anticoagulant and antithrombotic agent in the clinical setting for nearly a century. Heparin …

The efficiency of de novo synthesis of hyaluronic acid (HA) using Pasteurella multocida
hyaluronate synthase (PmHAS) is limited by its low catalytic activity during the initial reaction …

Glycoconjugates have great potential to improve human health in a multitude of different
ways and fields. Prominent examples are human milk oligosaccharides and …