Cryptosporidium spp are well recognised as causes of diarrhoeal disease during
waterborne epidemics and in immunocompromised hosts. Studies have also drawn …

Toxoplasma gondii causes fatal and debilitating brain and eye diseases. Medicines that are
currently used to treat toxoplasmosis commonly have toxic side effects and require …

New therapies are needed for the treatment of toxoplasmosis, which is a disease caused by
the protozoan parasite Toxoplasma gondii. To this end, we previously developed a potent …

Abstract The Pathogen Box is a 400‐strong collection of drug‐like compounds, selected for
their potential against several of the world's most important neglected tropical diseases …

Abstract Bumped Kinase Inhibitors, targeting Calcium-dependent Protein Kinase 1 in
apicomplexan parasites with a glycine gatekeeper, are promising new therapeutics for …

Calcium dependent protein kinase 1 (CDPK1) is an essential enzyme in the opportunistic
pathogen Toxoplasma gondii. CDPK1 controls multiple processes that are critical to the …

Toxoplasma gondii is an obligatory intracellular pathogen that causes life threatening illness
in immunodeficient individuals, miscarriage in pregnant woman, and blindness in newborn …

We report on the in vitro effects of the bumped kinase inhibitor 1294 (BKI-1294) in cultures of
virulent Neospora caninum isolates Nc-Liverpool (Nc-Liv) and Nc-Spain7 and in two strains …

Introduction: Despite the fact that diseases caused by protozoan parasites represent serious
challenges for public health, animal production and welfare, only a limited panel of drugs …

Many life-cycle processes in parasites are regulated by protein phosphorylation. Hence,
disruption of essential protein kinase function has been explored for therapy of parasitic …