The role of vitamin K in cholestatic liver disease

H Sultana, M Komai, H Shirakawa - Nutrients, 2021 - mdpi.com
Vitamin K (VK) is a ligand of the pregnane X receptor (PXR), which plays a critical role in the
detoxification of xenobiotics and metabolism of bile acids. VK1 may reduce the risk of death …

Anxiety and depression in patients with primary biliary cholangitis: Current insights and impact on quality of life

T Sivakumar, KV Kowdley - Hepatic Medicine: Evidence and …, 2021 - Taylor & Francis
Primary biliary cholangitis (PBC), formerly known as primary biliary cirrhosis, is a chronic
cholestatic immune-mediated liver disease characterized by injury to intrahepatic bile ducts …

Risk of fractures and postfracture mortality in 3980 people with primary biliary cholangitis: a population‐based cohort study

J Schönau, A Wester, JM Schattenberg… - Journal of internal …, 2023 - Wiley Online Library
Background Morbidity in primary biliary cholangitis (PBC) is multifactorial. Osteoporosis
related to cholestasis is an extrahepatic complication of PBC. It is not fully established to …

Long non-coding RNA MIR22HG promotes osteogenic differentiation of bone marrow mesenchymal stem cells via PTEN/ AKT pathway

C Jin, L Jia, Z Tang, Y Zheng - Cell death & disease, 2020 - nature.com
Osteoporosis is a prevalent metabolic bone disease characterized by low bone mineral
density and degenerative disorders of bone tissues. Previous studies showed the abnormal …

原发性胆汁性胆管炎的诊断和治疗指南(2021).

尤红, 贾继东 - Journal of Clinical Hepatology/Linchuang …, 2022 - search.ebscohost.com
2015 年中华医学会肝病学分会和中华医学会消化病学分会制订了我国第一个原发性胆汁性胆管
炎(primary biliary cholangitis, PBC) 的专家共识. 近年来国内外有关研究为PBC …

[HTML][HTML] Osteosarcopenia in autoimmune cholestatic liver diseases: Causes, management, and challenges

N Pugliese, I Arcari, A Aghemo, AG Lania… - World Journal of …, 2022 - ncbi.nlm.nih.gov
Primary biliary cholangitis and primary sclerosing cholangitis (PSC) are the most common
cholestatic liver diseases (CLD) in adults and are both characterized by an immune …

[HTML][HTML] Prevalence and risk factors of osteoporosis detected by dual-energy X-ray absorptiometry among Chinese patients with primary biliary cholangitis

JL Chen, Y Liu, YF Bi, XB Wang - World Journal of …, 2023 - ncbi.nlm.nih.gov
Prevalence and risk factors of osteoporosis detected by dual-energy X-ray absorptiometry
among Chinese patients with primary biliary cholangitis - PMC Back to Top Skip to main …

Primary biliary cholangitis

J Trivella, C Levy - Hepatology, 2025 - Elsevier
Primary biliary cholangitis (PBC) is a chronic autoimmune disease causing inflammation in
interlobular bile ducts, leading to cholestasis, hepatocyte damage, and fibrosis. Often …

Osteoporosis and Primary Biliary Cholangitis: A Trans-ethnic Mendelian Randomization Analysis

Y Wu, Q Qian, Q Liu, R Wang, X Pu, Y Li… - Clinical Reviews in …, 2024 - Springer
Osteoporosis is a major clinical problem in many autoimmune diseases, including primary
biliary cholangitis (PBC), the most common autoimmune liver disease. Osteoporosis is a …

[HTML][HTML] Influence of socioeconomic factors on liver transplant survival outcomes in patients with autoimmune liver disease in the United States

L Sierra, A Marenco-Flores, R Barba, D Goyes… - Annals of …, 2024 - Elsevier
Abstract Introduction and Objectives Autoimmune liver diseases (AILDs): autoimmune
hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC) …