Subclinical acute kidney injury in COVID-19: possible mechanisms and future perspectives
RP Silva-Aguiar, DE Teixeira, RAS Peres… - International Journal of …, 2022 - mdpi.com
Since the outbreak of COVID-19 disease, a bidirectional interaction between kidney disease
and the progression of COVID-19 has been demonstrated. Kidney disease is an …
and the progression of COVID-19 has been demonstrated. Kidney disease is an …
The intrarenal renin-angiotensin system in hypertension
RM Carey - Advances in chronic kidney disease, 2015 - Elsevier
The renin-angiotensin system (RAS) is a well-studied hormonal cascade controlling fluid
and electrolyte balance and blood pressure through systemic actions. The classical RAS …
and electrolyte balance and blood pressure through systemic actions. The classical RAS …
High glucose reduces megalin-mediated albumin endocytosis in renal proximal tubule cells through protein kinase B O-GlcNAcylation
D de Barros Peruchetti, RP Silva-Aguiar… - Journal of Biological …, 2018 - ASBMB
The role of albumin reabsorption in proximal tubule (PT) cells has emerged as an important
factor in the genesis of albuminuria observed in the early stages of diabetes. Evidence has …
factor in the genesis of albuminuria observed in the early stages of diabetes. Evidence has …
The effects of renal denervation on blood pressure, cardiac hypertrophy, and sympathetic activity during the established phase of hypertension in spontaneously …
M Katsuki, K Shinohara, S Kinugawa… - Hypertension Research, 2024 - nature.com
This study aimed to investigate whether renal denervation (RDN) reduces blood pressure
and attenuates cardiac hypertrophy with decreasing sympathetic activity in spontaneously …
and attenuates cardiac hypertrophy with decreasing sympathetic activity in spontaneously …
O-GlcNAcylation reduces proximal tubule protein reabsorption and promotes proteinuria in spontaneously hypertensive rats
RP Silva-Aguiar, NCF Bezerra, MC Lucena… - Journal of Biological …, 2018 - ASBMB
Hypertensive individuals are at greater risk for developing chronic kidney disease (CKD).
Reducing proteinuria has been suggested as a possible therapeutic approach to treat CKD …
Reducing proteinuria has been suggested as a possible therapeutic approach to treat CKD …
[HTML][HTML] A high salt diet induces tubular damage associated with a pro-inflammatory and pro-fibrotic response in a hypertension-independent manner
DE Teixeira, DB Peruchetti, MC Souza… - … et Biophysica Acta (BBA …, 2020 - Elsevier
High salt diet (HSD), considered a public health problem worldwide, is associated with
chronic degenerative diseases including renal diseases. However, little is known about the …
chronic degenerative diseases including renal diseases. However, little is known about the …
Megalin-mediated albumin endocytosis in renal proximal tubules is involved in the antiproteinuric effect of angiotensin II type 1 receptor blocker in a subclinical acute …
DB Peruchetti, PFR Barahuna-Filho… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Background Tubule-interstitial injury (TII) is one of the mechanisms involved in the
progression of renal diseases with progressive proteinuria. Angiotensin II (Ang II) type 1 …
progression of renal diseases with progressive proteinuria. Angiotensin II (Ang II) type 1 …
Inhibition of 15-PGDH prevents ischemic renal injury by the PGE2/EP4 signaling pathway mediating vasodilation, increased renal blood flow, and increased …
HJ Kim, SH Kim, M Kim, HJ Baik… - American Journal …, 2020 - journals.physiology.org
In the present study, we demonstrated the marked activity of SW033291, an inhibitor of 15-
hydoxyprostaglandin dehydrogenase (15-PGDH), in preventing acute kidney injury (AKI) in …
hydoxyprostaglandin dehydrogenase (15-PGDH), in preventing acute kidney injury (AKI) in …
N-Palmitoylethanolamide protects the kidney from hypertensive injury in spontaneously hypertensive rats via inhibition of oxidative stress
Hypertension is an important risk factor for kidney failure and renal events in the general
population. Palmitoylethanolamide (PEA) is a member of the fatty acid ethanolamine family …
population. Palmitoylethanolamide (PEA) is a member of the fatty acid ethanolamine family …
The renin–angiotensin–aldosterone system: Role in pathogenesis and potential therapeutic target in COVID‐19
CL Braga, RP Silva‐Aguiar, D Battaglini… - Pharmacology …, 2020 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19), caused by the SARS‐CoV‐2 novel
coronavirus, has spread worldwide causing high fatality rates. Neither a vaccine nor specific …
coronavirus, has spread worldwide causing high fatality rates. Neither a vaccine nor specific …