Loss of normal kidney function affects more than 10% of the population and contributes to
morbidity and mortality. Kidney diseases are currently treated with immunosuppressive …

Genetic coding variants in APOL1, which encodes apolipoprotein L1 (APOL1), were
identified in 2010 and are relatively common among individuals of sub-Saharan African …

Glomerular disease, be it primary or secondary, occurring in the setting of systemic
autoimmune diseases, infections, drugs, or malignancy, affects individuals of all ages. In …

HIV-positive individuals are at increased risk for kidney disease, including HIV-associated
nephropathy, noncollapsing focal segmental glomerulosclerosis, immune-complex kidney …

Soluble urokinase plasminogen activator receptor (suPAR) independently predicts chronic
kidney disease (CKD) incidence and progression. Apolipoprotein L1 (APOL1) gene variants …

Genetic methodologies are improving our understanding of the pathophysiology in diverse
diseases. Breakthroughs have been particularly impressive in nephrology, for which marked …

Kidney Diseases Associated with Human Immunodeficiency Virus Infection | NEJM Skip to
main content NEJM Group Follow Us Facebook Twitter Instagram YouTube LinkedIn Prepare …

Genetic variants in the APOL1 gene, found only in individuals of recent African ancestry,
greatly increase risk of multiple types of kidney disease. These APOL1 kidney risk alleles …

The C-terminal variants G1 and G2 of apolipoprotein L1 (APOL1) confer human resistance
to the sleeping sickness parasite Trypanosoma rhodesiense, but they also increase the risk …

Population genetic approaches have uncovered a strong association between kidney
diseases and two sequence variants of the APOL1 gene, called APOL1 risk variant G1 and …