Polyamines are essential for the proliferation, differentiation, and development of
eukaryotes. They include spermine, spermidine, and the diamine precursor putrescine, and …

Accumulating recent evidence indicates that the human microbiome plays essential roles in
pathophysiological states, including cancer. The tumor microbiome, an emerging concept …

Background The tumor suppressor p53 is an important regulator that controls various
cellular networks, including cell differentiation. Interestingly, some studies suggest that p53 …

The acetylating enzyme, spermidine/spermine N 1-acetyltransferase, participates in
polyamine homeostasis by regulating polyamine export and catabolism. Previously, we …

The peroxisome proliferator-activated receptor (PPAR) γ is one member of the nuclear
receptor superfamily that contains in excess of 80 described receptors. PPARγ activators are …

Background Tumorigenesis is associated with changes in gene expression and involves
many pathways. Dysregulated genes include" housekeeping" genes that are often used for …

Background Although many diseases have been well characterized at the molecular level,
the underlying mechanisms are often unknown. Nearly half of all human genes remain …

Mismanagement of bacterial infection therapies has undermined the reliability and efficacy
of antibiotic treatments, producing a profound crisis of the antibiotic drug market. It is by now …

Colorectal cancer (CRC) is one of the major public health and socio-economic problems,
which management demands the development of non-invasive screening tests. Assessment …

The urea cycle (UC) removes the excess nitrogen and ammonia generated by nitrogen-
containing compound composites or protein breakdown in the human body. Research has …