KATP channels are integral to the functions of many cells and tissues. The use of
electrophysiological methods has allowed for a detailed characterization of KATP channels …

Cardiac K channels are critical determinants of cardiac excitability. In hypertrophied and
failing myocardium, alterations in the expression and activity of voltage-gated K channels …

The sarcolemmal adenosine triphosphate (ATP)-sensitive K+ (sarcKATP) channel in the
heart is a hetero-octamer comprising the pore-forming subunit Kir6. 2 and the regulatory …

Objective To evaluate the involvement of the sensory and autonomic nervous system in
amyotrophic lateral sclerosis (ALS) and to determine whether TDP-43/pTDP-43 deposits in …

To accomplish its life-supporting function of pumping oxygenated blood around the body,
the heart contracts and relaxes in a regulated fashion. This contraction process is preceded …

Rationale Deterioration of ventricular fibrillation (VF) into asystole or severe bradycardia
(electrical failure) heralds a fatal outcome of cardiac arrest. The role of metabolism in the …

Introduction Nicorandil, a vasodilatory drug used to treat angina, was reported to protect
against myocardial ischemia-reperfusion injury in various animal models. However, its …

The aim of the investigation is to study the frequency structure of electrocardiogram (ECG)
during long-duration ventricular fibrillation (VF) in the canine heart using fast Fourier …

Mitochondrial membrane potential (ΔΨm) depolarization has been implicated in the loss of
excitability (asystole) during global ischemia, which is relevant for the success of …

Ventricular fibrillation (VF) in the globally ischemic heart is characterized by a progressive
electrical depression manifested as a decline in the VF excitation rate (VFR) and loss of …