The epidemiology of Parkinson's disease: risk factors and prevention

A Ascherio, MA Schwarzschild - The Lancet Neurology, 2016 - thelancet.com
Since 2006, several longitudinal studies have assessed environmental or behavioural
factors that seem to modify the risk of developing Parkinson's disease. Increased risk of …

Pesticides: an update of human exposure and toxicity

S Mostafalou, M Abdollahi - Archives of toxicology, 2017 - Springer
Pesticides are a family of compounds which have brought many benefits to mankind in the
agricultural, industrial, and health areas, but their toxicities in both humans and animals …

Preventing Parkinson's disease: an environmental agenda

BR De Miranda, SM Goldman… - Journal of …, 2022 - journals.sagepub.com
Fueled by aging populations and continued environmental contamination, the global burden
of Parkinson's disease (PD) is increasing. The disease, or more appropriately diseases …

[HTML][HTML] Neurotoxicity of pesticides–A link to neurodegeneration

B Vellingiri, M Chandrasekhar, SS Sabari… - Ecotoxicology and …, 2022 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disorder which mainly targets motor
symptoms such as tremor, rigidity, bradykinesia and postural instability. The physiological …

The MPTP story

JW Langston - Journal of Parkinson's disease, 2017 - content.iospress.com
The identification of MPTP, a relatively simple compound which causes selective
degeneration of the substantia nigra after systemic administration, has had an a significant …

Environmental toxins and Parkinson's disease

SM Goldman - Annual review of pharmacology and toxicology, 2014 - annualreviews.org
Parkinson's disease (PD) is a chronic, progressive, disabling neurodegenerative disorder
that begins in mid to late life and is characterized by motor impairment, autonomic …

Association between Parkinson's disease and cigarette smoking, rural living, well-water consumption, farming and pesticide use: systematic review and meta-analysis

CB Breckenridge, C Berry, ET Chang, RL Sielken Jr… - PloS one, 2016 - journals.plos.org
Objective Bradford Hill's viewpoints were used to conduct a weight-of-the-evidence
assessment of the association between Parkinson's disease (PD) and rural living, farming …

Environmental exposures and Parkinson's disease

S Nandipati, I Litvan - International journal of environmental research and …, 2016 - mdpi.com
Parkinson's disease (PD) affects millions around the world. The Braak hypothesis proposes
that in PD a pathologic agent may penetrate the nervous system via the olfactory bulb, gut …

Environment, lifestyle, and Parkinson's disease: implications for prevention in the next decade

C Marras, CG Canning, SM Goldman - Movement Disorders, 2019 - Wiley Online Library
There is evidence from observational studies for a role of a number of environmental
exposures and lifestyle habits in modulating the risk for Parkinson's disease. Environmental …

The body, the brain, the environment, and Parkinson's disease

ER Dorsey, BR De Miranda… - Journal of …, 2024 - journals.sagepub.com
The brain-and body-first models of Lewy body disorders predict that aggregated alpha-
synuclein pathology usually begins in either the olfactory system or the enteric nervous …