“Functional cure” is being pursued as the ultimate endpoint of antiviral treatment in chronic
hepatitis B (CHB), which is characterized by loss of HBsAg whether or not anti-HBs …

Next-generation sequencing has revealed cancer genomic landscapes, in which over 100
driver genes that, when altered by intragenic mutations, can promote oncogenesis. MYD88 …

Chronic hepatitis B is caused by prolonged infection with the hepatitis B virus (HBV), which
can substantially increase the risk of developing liver disease. Despite the development of …

The last few years have seen a resurgence of activity in the hepatitis B drug pipeline, with
many compounds in various stages of development. This review aims to provide a …

Chronic hepatitis B (CHB) infection remains a serious public health problem worldwide;
however, the relationship between cholesterol levels and CHB remains unclear. We isolated …

With its 78 million chronic carriers, hepatitis B virus (HBV) infection is still one of the leading
public health challenges in China. Over the last two decades, China has made great …

Chronic hepatitis B virus (HBV) infection is one of the main causes of liver diseases, of which
the natural history and clinical outcomes are associated with the role of B cells. As humoral …

Abstract Hepatitis B Virus (HBV) persists in infected hepatocytes as an episomal covalently-
closed-circular DNA mini-chromosome, called cccDNA. As the main nuclear transcription …

Objective The purpose of this study is to develop an anti-PDL1-based interferon (IFN) fusion
protein to overcome the chronic hepatitis B virus (HBV)-induced immune tolerance, and …

Chronic hepatitis B virus (HBV) infection is a major global health burden causing severe
complications like liver cirrhosis or hepatocellular carcinoma. Curative treatment options are …