Abstract Interleukin 12 (IL-12) seemed to represent the ideal candidate for tumor
immunotherapy, due to its ability to activate both innate (NK cells) and adaptive (cytotoxic T …

Abstract Interferon-γ (IFN-γ) coordinates a diverse array of cellular programs through
transcriptional regulation of immunologically relevant genes. This article reviews the current …

The suggestion that antigen-presenting cells (APCs) produce interferon γ (IFN-γ) is
controversial because it conflicts with the initial paradigm in which the production of IFN-γ …

IFN-γ rapidly primes the macrophage via JAK1/2-STAT1 pathway so that it can subsequently
undergo a slower classical type 1 activation upon exposure to T helper (Th) 1 cytokines such …

The interferon (IFN)‐γ component of the immune response plays an essential role in
combating infectious and non‐infectious diseases. Induction of IFN‐γ secretion by human T …

Rheumatoid arthritis (RA) is a common autoimmune chronic inflammatory joint disease,
characterized by macrophage and lymphocyte infiltration, proliferation of synovial …

Infectious bronchitis virus (IBV) replicates in the epithelial cells of trachea and lungs of
chicken, however the mechanism of generation of innate immune response against IBV …

Objective—Although IL-18 has been implicated in atherosclerotic lesion development, little
is known about its role in advanced atherosclerotic plaques. This study aims to assess the …

Interferon (IFN)-γ is important to the immune defense against intracellular pathogens and
specifically the ability of macrophages to control Mycobacterium tuberculosis (MTB) …

Substantial attention has been paid to the role of the toll-like receptor (TLR) ligands of late
and their role in regulating the innate immune response. They serve as exogenous danger …