The hematopoietic system produces new blood cells throughout life. Mature blood cells all
derived from a pool of rare long-lived hematopoietic stem cells (HSCs) that are mostly …

Significance: The precise role and impact of reactive oxygen species (ROS) in stem cells,
which are essential for lifelong tissue homeostasis and regeneration, remain of significant …

Hematopoietic stem cell (HSC) aging is accompanied by hematopoietic reconstitution
dysfunction, including loss of regenerative and engraftment ability, myeloid differentiation …

Forkhead box class O family member proteins (FoxOs) are evolutionarily conserved
transcription factors for their highly conserved DNA-binding domain. In mammalian species …

Forkhead box (FOX) proteins are multifaceted transcription factors that are significantly
implicated in cancer, with various critical roles in biological processes. Herein, we provide …

Aging drives the genetic and epigenetic changes that result in a decline in hematopoietic
stem cell (HSC) functioning. Such changes lead to aging-related hematopoietic/immune …

Aging attenuates the overall responsiveness of the immune system to eradicate pathogens.
The increased production of pro-inflammatory cytokines by innate immune cells under basal …

The forkhead box O3 (FOXO3, or FKHRL1) protein is a member of the FOXO subclass of
transcription factors. FOXO proteins were originally identified as regulators of insulin-related …

FOXO proteins are a sub-group of a superfamily of forkhead box (FOX)-containing
transcription factors (TFs). FOXOs play an important role in regulating a plethora of …

Significance: Stem cell activation and differentiation occur along changes in cellular
metabolism. Metabolic transitions translate into changes in redox balance, cell signaling …