Treatment of toxoplasmosis: Current options and future perspectives

N Konstantinovic, H Guegan, T Stäjner, S Belaz… - Food and waterborne …, 2019 - Elsevier
Toxoplasmosis is a worldwide parasitic disease infecting about one third of humans, with
possible severe outcomes in neonates and immunocompromised patients. Despite …

Toxoplasma gondii: CD8 T Cells Cry for CD4 Help

IA Khan, SJ Hwang, M Moretto - Frontiers in cellular and infection …, 2019 - frontiersin.org
Toxoplasma gondii, an apicomplexan parasite, is a pathogenic protozoan that can infect the
central nervous system. In pregnant women, infection can result in congenital problems of …

Dihydroartemisinin regulates the immune system by promotion of CD8+ T lymphocytes and suppression of B cell responses

T Zhang, Y Zhang, N Jiang, X Zhao, X Sang… - Science China Life …, 2020 - Springer
Artemisia annua is an anti-fever herbal medicine first described in traditional Chinese
medicine 1,000 years ago. Artemisinin, the extract of A. annua, and its derivatives …

Characterization of a multi-epitope peptide with selective MHC-binding capabilities encapsulated in PLGA nanoparticles as a novel vaccine candidate against …

M Roozbehani, R Falak, M Mohammadi, A Hemphill… - Vaccine, 2018 - Elsevier
No effective human vaccine against Toxoplasma gondii (T. gondii) has yet been developed;
however, a protective vaccine using immunogenic peptides in a safe delivery vehicle system …

Adaptive immunity in schizophrenia: functional implications of T cells in the etiology, course and treatment

M Debnath - Journal of Neuroimmune Pharmacology, 2015 - Springer
Schizophrenia is a severe and highly complex neurodevelopmental disorder with an
unknown etiopathology. Recently, immunopathogenesis has emerged as one of the most …

T cell exhaustion in protozoan disease

JP Gigley, R Bhadra, MM Moretto, IA Khan - Trends in parasitology, 2012 - cell.com
Protozoan parasites cause severe morbidity and mortality in humans worldwide, especially
in developing countries where access to chemotherapeutic agents is limited. Although …

PD-1–Mediated Attrition of Polyfunctional Memory CD8+ T Cells in Chronic Toxoplasma Infection

R Bhadra, JP Gigley, IA Khan - The Journal of infectious …, 2012 - academic.oup.com
We reported earlier that during chronic toxoplasmosis CD8+ T cells become functionally
exhausted with concomitant PD-1 upregulation, leading to eventual host mortality. However …

Immune system roles in pathogenesis, prognosis, control, and treatment of Toxoplasma gondii infection

MM Jafari, ZA Tabrizi, MS Dayer… - International …, 2023 - Elsevier
Toxoplasma gondii is the protozoan causative agent of toxoplasmosis in humans and warm-
blooded animals. Recent studies have illustrated that the immune system plays a pivotal role …

Veterinary vaccines against toxoplasmosis

E Hiszczyńska-Sawicka, JM Gatkowska… - Parasitology, 2014 - cambridge.org
Toxoplasma gondii is a cosmopolitan protozoan parasite that infects a wide range of
mammal and bird species. Common infection leads to high economic (eg abortions in …

A Proinflammatory Immune Response Might Determine Toxoplasma gondii Vertical Transmission and Severity of Clinical Features in Congenitally Infected Newborns

F Gómez-Chávez, I Cañedo-Solares… - Frontiers in …, 2020 - frontiersin.org
Toxoplasma gondii is the etiological agent of toxoplasmosis. Mother-to-child transmission of
this parasite can occur during pregnancy. Newborns with congenital toxoplasmosis may …