The endosomal-lysosomal system is made up of a set of intracellular membranous
compartments that dynamically interconvert, which is comprised of early endosomes …

Autophagy and endocytosis deliver unneeded cellular materials to lysosomes for
degradation. Beyond processing cellular waste, lysosomes release metabolites and ions …

Mitochondrial dysfunction is an established hallmark of aging and neurodegenerative
disorders such as Down syndrome (DS) and Alzheimer's disease (AD). Using a high …

Alzheimer's disease (AD) is one of the biggest human health threats due to increases in
aging of the global population. Unfortunately, drugs for treating AD have been largely …

Abnormalities of the endosomal–lysosomal network (ELN) are a signature feature of
Alzheimer's disease (AD). These include the earliest known cytopathology that is specific to …

Defective autophagy contributes to Alzheimer disease (AD) pathogenesis although
evidence is conflicting on whether multiple stages are impaired. Here, for the first time, we …

The term “propagon” is used to define proteins that may transmit misfolding in vitro, in
tissues or in organisms. Among propagons, misfolded tau is thought to be involved in the …

A major feature of Alzheimer's disease (AD) is the loss of noradrenergic locus coeruleus
(LC) projection neurons that mediate attention, memory, and arousal. However, the extent to …

Defects in membrane trafficking are hallmarks of neurodegeneration. Rab GTPases are key
regulators of membrane trafficking. Alterations of Rab GTPases, or the membrane …

Lipids are key regulators of brain function and have been increasingly implicated in
neurodegenerative disorders including Alzheimer disease (AD). Here, a systems-based …