Organ‐on‐a‐Chip Systems: microengineering to biomimic living systems

F Zheng, F Fu, Y Cheng, C Wang, Y Zhao, Z Gu - Small, 2016 - Wiley Online Library
“Organ‐on‐a‐chip” systems integrate microengineering, microfluidic technologies, and
biomimetic principles to create key aspects of living organs faithfully, including critical …

[HTML][HTML] Genipin-crosslinked chitosan gels and scaffolds for tissue engineering and regeneration of cartilage and bone

RAA Muzzarelli, M El Mehtedi, C Bottegoni, A Aquili… - Marine drugs, 2015 - mdpi.com
The present review article intends to direct attention to the technological advances made
since 2009 in the area of genipin-crosslinked chitosan (GEN-chitosan) hydrogels. After a …

[HTML][HTML] Microfluidic organ/body-on-a-chip devices at the convergence of biology and microengineering

AR Perestrelo, ACP Águas, A Rainer, G Forte - Sensors, 2015 - mdpi.com
Recent advances in biomedical technologies are mostly related to the convergence of
biology with microengineering. For instance, microfluidic devices are now commonly found …

[HTML][HTML] Prolonged culture of aligned skeletal myotubes on micromolded gelatin hydrogels

A Bettadapur, GC Suh, NA Geisse, ER Wang, C Hua… - Scientific reports, 2016 - nature.com
In vitro models of skeletal muscle are critically needed to elucidate disease mechanisms,
identify therapeutic targets and test drugs pre-clinically. However, culturing skeletal muscle …

Physical properties imparted by genipin to chitosan for tissue regeneration with human stem cells: A review

RAA Muzzarelli, M El Mehtedi, C Bottegoni… - International journal of …, 2016 - Elsevier
Genipin is a fully assessed non-cytotoxic crosslinking compound. The chitosan| genipin
physical properties such as morphology, roughness, porosity, hydrophilicity, ζ-potential …

Vascular smooth muscle cell functional contractility depends on extracellular mechanical properties

KE Steucke, PV Tracy, ES Hald, JL Hall… - Journal of biomechanics, 2015 - Elsevier
Vascular smooth muscle cells' primary function is to maintain vascular homeostasis through
active contraction and relaxation. In diseases such as hypertension and atherosclerosis, this …

[图书][B] 3D and 4D printing in biomedical applications: process engineering and additive manufacturing

M Maniruzzaman - 2018 - books.google.com
A professional guide to 3D and 4D printing technology in the biomedical and
pharmaceutical fields 3D and 4D Printing in Biomedical Applications offers an authoritative …

Automated fabrication of photopatterned gelatin hydrogels for organ-on-chips applications

JC Nawroth, LL Scudder, RT Halvorson… - …, 2018 - iopscience.iop.org
Organ-on-chip platforms aim to improve preclinical models for organ-level responses to
novel drug compounds. Heart-on-a-chip assays in particular require tissue engineering …

Multi-scale modeling of the cardiovascular system: disease development, progression, and clinical intervention

Y Zhang, VH Barocas, SA Berceli, CE Clancy… - Annals of biomedical …, 2016 - Springer
Cardiovascular diseases (CVDs) are the leading cause of death in the western world. With
the current development of clinical diagnostics to more accurately measure the extent and …

Organ-on-a-chip: new platform for biological analysis

F An, Y Qu, X Liu, R Zhong… - AnAlyticAl chemistry …, 2015 - journals.sagepub.com
Direct detection and analysis of biomolecules and cells in physiological microenvironment is
urgently needed for fast evaluation of biology and pharmacy. The past several years have …