Inositol pyrophosphate dynamics reveals control of the yeast phosphate starvation program through 1, 5-IP8 and the SPX domain of Pho81
Eukaryotic cells control inorganic phosphate to balance its role as essential macronutrient
with its negative bioenergetic impact on reactions liberating phosphate. Phosphate …
with its negative bioenergetic impact on reactions liberating phosphate. Phosphate …
Inositol polyphosphate–protein interactions: Implications for microbial pathogenicity
S Lev, B Bowring, D Desmarini… - Cellular …, 2021 - Wiley Online Library
Inositol polyphosphates (IPs) and inositol pyrophosphates (PP–IPs) regulate diverse cellular
processes in eukaryotic cells. IPs and PP–IPs are highly negatively charged and exert their …
processes in eukaryotic cells. IPs and PP–IPs are highly negatively charged and exert their …
Modulation of fungal phosphate homeostasis by the plant hormone strigolactone
JM Bradley, M Bunsick, G Ly, B Aquino, FZ Wang… - Molecular Cell, 2024 - cell.com
Inter-kingdom communication through small molecules is essential to the coexistence of
organisms in an ecosystem. In soil communities, the plant root is a nexus of interactions for a …
organisms in an ecosystem. In soil communities, the plant root is a nexus of interactions for a …
Arg1 from Cryptococcus neoformans lacks PI3 kinase activity and conveys virulence roles via its IP3-4 kinase activity
Inositol tris/tetrakis phosphate kinases (IP3-4K) in the human fungal priority pathogens,
Cryptococcus neoformans (Cn Arg1) and Candida albicans (Ca Ipk2), convey numerous …
Cryptococcus neoformans (Cn Arg1) and Candida albicans (Ca Ipk2), convey numerous …
Dysregulating PHO Signaling via the CDK Machinery Differentially Impacts Energy Metabolism, Calcineurin Signaling, and Virulence in Cryptococcus neoformans
Fungal pathogens uniquely regulate phosphate homeostasis via the cyclin-dependent
kinase (CDK) signaling machinery of the phosphate acquisition (PHO) pathway (Pho85 …
kinase (CDK) signaling machinery of the phosphate acquisition (PHO) pathway (Pho85 …
Blocking polyphosphate mobilization inhibits Pho4 activation and virulence in the pathogen Candida albicans
Y Ahmed, MAC Ikeh, DM MacCallum, AM Day… - MBio, 2022 - Am Soc Microbiol
The ability of pathogenic fungi to obtain essential nutrients from the host is vital for virulence.
In Candida albicans, acquisition of the macronutrient phosphate is regulated by the Pho4 …
In Candida albicans, acquisition of the macronutrient phosphate is regulated by the Pho4 …
[PDF][PDF] Dysregulating PHO Signaling via the CDK Machinery Differentially Impacts Energy Metabolism, Calcineurin Signaling, and Virulence in C. neoformans
SH Lee, A Toh-e, N Proschogo, T Savage… - 2023 - researchgate.net
Fungal pathogens uniquely regulate phosphate homeostasis via the cyclindependent
kinase (CDK) signaling machinery of the phosphate acquisition (PHO) pathway (Pho85 …
kinase (CDK) signaling machinery of the phosphate acquisition (PHO) pathway (Pho85 …